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Systematic functional analysis of SARS-CoV-2 proteins uncovers viral innate immune antagonists and remaining vulnerabilities.
Hayn M, Hirschenberger M, Koepke L, Nchioua R, Straub JH, Klute S, Hunszinger V, Zech F, Prelli Bozzo C, Aftab W, Christensen MH, Conzelmann C, Müller JA, Srinivasachar Badarinarayan S, Stürzel CM, Forne I, Stenger S, Conzelmann KK, Münch J, Schmidt FI, Sauter D, Imhof A, Kirchhoff F, Sparrer KMJ. Hayn M, et al. Among authors: schmidt fi. Cell Rep. 2021 May 18;35(7):109126. doi: 10.1016/j.celrep.2021.109126. Epub 2021 Apr 27. Cell Rep. 2021. PMID: 33974846 Free PMC article.
RNA-binding proteins hnRNPM and ELAVL1 promote type-I interferon induction downstream of the nucleic acid sensors cGAS and RIG-I.
Kirchhoff A, Herzner AM, Urban C, Piras A, Düster R, Mahlberg J, Grünewald A, Schlee-Guimarães TM, Ciupka K, Leka P, Bootz RJ, Wallerath C, Hunkler C, de Regt AK, Kümmerer BM, Christensen MH, Schmidt FI, Lee-Kirsch MA, Günther C, Kato H, Bartok E, Hartmann G, Geyer M, Pichlmair A, Schlee M. Kirchhoff A, et al. Among authors: schmidt fi. EMBO J. 2024 Dec 20. doi: 10.1038/s44318-024-00331-x. Online ahead of print. EMBO J. 2024. PMID: 39707025 Free article.
NIS-Seq enables cell-type-agnostic optical perturbation screening.
Fandrey CI, Jentzsch M, Konopka P, Hoch A, Blumenstock K, Zackria A, Maasewerd S, Lovotti M, Lapp DJ, Gohr FN, Suwara P, Świeżewski J, Rossnagel L, Gobs F, Cristodaro M, Muhandes L, Behrendt R, Lam MC, Walgenbach KJ, Bald T, Schmidt FI, Latz E, Schmid-Burgk JL. Fandrey CI, et al. Among authors: schmidt fi. Nat Biotechnol. 2024 Dec 19. doi: 10.1038/s41587-024-02516-5. Online ahead of print. Nat Biotechnol. 2024. PMID: 39702735
Multi-omics characterization of the monkeypox virus infection.
Huang Y, Bergant V, Grass V, Emslander Q, Hamad MS, Hubel P, Mergner J, Piras A, Krey K, Henrici A, Öllinger R, Tesfamariam YM, Dalla Rosa I, Bunse T, Sutter G, Ebert G, Schmidt FI, Way M, Rad R, Bowie AG, Protzer U, Pichlmair A. Huang Y, et al. Among authors: schmidt fi. Nat Commun. 2024 Aug 8;15(1):6778. doi: 10.1038/s41467-024-51074-6. Nat Commun. 2024. PMID: 39117661 Free PMC article.
Brain endothelial GSDMD activation mediates inflammatory BBB breakdown.
Wei C, Jiang W, Wang R, Zhong H, He H, Gao X, Zhong S, Yu F, Guo Q, Zhang L, Schiffelers LDJ, Zhou B, Trepel M, Schmidt FI, Luo M, Shao F. Wei C, et al. Among authors: schmidt fi. Nature. 2024 May;629(8013):893-900. doi: 10.1038/s41586-024-07314-2. Epub 2024 Apr 17. Nature. 2024. PMID: 38632402
54 results