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Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo.
Nat Chem Biol. 2021 Sep;17(9):954-963. doi: 10.1038/s41589-021-00786-7. Epub 2021 May 10.
Nat Chem Biol. 2021.
PMID: 33972797
Free PMC article.
Identification of a potent and selective covalent Pin1 inhibitor.
Pinch BJ, Doctor ZM, Nabet B, Browne CM, Seo HS, Mohardt ML, Kozono S, Lian X, Manz TD, Chun Y, Kibe S, Zaidman D, Daitchman D, Yeoh ZC, Vangos NE, Geffken EA, Tan L, Ficarro SB, London N, Marto JA, Buratowski S, Dhe-Paganon S, Zhou XZ, Lu KP, Gray NS.
Pinch BJ, et al. Among authors: geffken ea.
Nat Chem Biol. 2020 Sep;16(9):979-987. doi: 10.1038/s41589-020-0550-9. Epub 2020 Jun 1.
Nat Chem Biol. 2020.
PMID: 32483379
Free PMC article.
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Direct Tumor Killing and Immunotherapy through Anti-SerpinB9 Therapy.
Jiang L, Wang YJ, Zhao J, Uehara M, Hou Q, Kasinath V, Ichimura T, Banouni N, Dai L, Li X, Greiner DL, Shultz LD, Zhang X, Sun ZJ, Curtin I, Vangos NE, Yeoh ZC, Geffken EA, Seo HS, Liu ZX, Heffron GJ, Shah K, Dhe-Paganon S, Abdi R.
Jiang L, et al. Among authors: geffken ea.
Cell. 2020 Nov 25;183(5):1219-1233.e18. doi: 10.1016/j.cell.2020.10.045.
Cell. 2020.
PMID: 33242418
Free PMC article.
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Binding and transport of SFPQ-RNA granules by KIF5A/KLC1 motors promotes axon survival.
Fukuda Y, Pazyra-Murphy MF, Silagi ES, Tasdemir-Yilmaz OE, Li Y, Rose L, Yeoh ZC, Vangos NE, Geffken EA, Seo HS, Adelmant G, Bird GH, Walensky LD, Marto JA, Dhe-Paganon S, Segal RA.
Fukuda Y, et al. Among authors: geffken ea.
J Cell Biol. 2021 Jan 4;220(1):e202005051. doi: 10.1083/jcb.202005051.
J Cell Biol. 2021.
PMID: 33284322
Free PMC article.
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Regulation of GTPase function by autophosphorylation.
Johnson CW, Seo HS, Terrell EM, Yang MH, KleinJan F, Gebregiworgis T, Gasmi-Seabrook GMC, Geffken EA, Lakhani J, Song K, Bashyal P, Popow O, Paulo JA, Liu A, Mattos C, Marshall CB, Ikura M, Morrison DK, Dhe-Paganon S, Haigis KM.
Johnson CW, et al. Among authors: geffken ea.
Mol Cell. 2022 Mar 3;82(5):950-968.e14. doi: 10.1016/j.molcel.2022.02.011. Epub 2022 Feb 23.
Mol Cell. 2022.
PMID: 35202574
Free PMC article.
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A novel β-catenin/BCL9 complex inhibitor blocks oncogenic Wnt signaling and disrupts cholesterol homeostasis in colorectal cancer.
Tanton H, Sewastianik T, Seo HS, Remillard D, Pierre RS, Bala P, Aitymbayev D, Dennis P, Adler K, Geffken E, Yeoh Z, Vangos N, Garbicz F, Scott D, Sethi N, Bradner J, Dhe-Paganon S, Carrasco RD.
Tanton H, et al.
Sci Adv. 2022 Apr 29;8(17):eabm3108. doi: 10.1126/sciadv.abm3108. Epub 2022 Apr 29.
Sci Adv. 2022.
PMID: 35486727
Free PMC article.
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Covalent disruptor of YAP-TEAD association suppresses defective Hippo signaling.
Fan M, Lu W, Che J, Kwiatkowski NP, Gao Y, Seo HS, Ficarro SB, Gokhale PC, Liu Y, Geffken EA, Lakhani J, Song K, Kuljanin M, Ji W, Jiang J, He Z, Tse J, Boghossian AS, Rees MG, Ronan MM, Roth JA, Mancias JD, Marto JA, Dhe-Paganon S, Zhang T, Gray NS.
Fan M, et al. Among authors: geffken ea.
Elife. 2022 Oct 27;11:e78810. doi: 10.7554/eLife.78810.
Elife. 2022.
PMID: 36300789
Free PMC article.
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Coupling of Airway Smooth Muscle Bitter Taste Receptors to Intracellular Signaling and Relaxation Is via Gαi1,2,3.
Kim D, Woo JA, Geffken E, An SS, Liggett SB.
Kim D, et al.
Am J Respir Cell Mol Biol. 2017 Jun;56(6):762-771. doi: 10.1165/rcmb.2016-0373OC.
Am J Respir Cell Mol Biol. 2017.
PMID: 28145731
Free PMC article.
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