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Structural analyses of the PKA RIIβ holoenzyme containing the oncogenic DnaJB1-PKAc fusion protein reveal protomer asymmetry and fusion-induced allosteric perturbations in fibrolamellar hepatocellular carcinoma.
Lu TW, Aoto PC, Weng JH, Nielsen C, Cash JN, Hall J, Zhang P, Simon SM, Cianfrocco MA, Taylor SS. Lu TW, et al. PLoS Biol. 2020 Dec 28;18(12):e3001018. doi: 10.1371/journal.pbio.3001018. eCollection 2020 Dec. PLoS Biol. 2020. PMID: 33370777 Free PMC article.
Gpr161 anchoring of PKA consolidates GPCR and cAMP signaling.
Bachmann VA, Mayrhofer JE, Ilouz R, Tschaikner P, Raffeiner P, Röck R, Courcelles M, Apelt F, Lu TW, Baillie GS, Thibault P, Aanstad P, Stelzl U, Taylor SS, Stefan E. Bachmann VA, et al. Among authors: lu tw. Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):7786-91. doi: 10.1073/pnas.1608061113. Epub 2016 Jun 28. Proc Natl Acad Sci U S A. 2016. PMID: 27357676 Free PMC article.
The In Situ Structure of Parkinson's Disease-Linked LRRK2.
Watanabe R, Buschauer R, Böhning J, Audagnotto M, Lasker K, Lu TW, Boassa D, Taylor S, Villa E. Watanabe R, et al. Among authors: lu tw. Cell. 2020 Sep 17;182(6):1508-1518.e16. doi: 10.1016/j.cell.2020.08.004. Epub 2020 Aug 11. Cell. 2020. PMID: 32783917 Free PMC article.
191 results