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Aldehyde dehydrogenase 2 plays a role in the bioactivation of nitroglycerin in humans.
Mackenzie IS, Maki-Petaja KM, McEniery CM, Bao YP, Wallace SM, Cheriyan J, Monteith S, Brown MJ, Wilkinson IB. Mackenzie IS, et al. Among authors: wilkinson ib. Arterioscler Thromb Vasc Biol. 2005 Sep;25(9):1891-5. doi: 10.1161/01.ATV.0000179599.71086.89. Epub 2005 Jul 28. Arterioscler Thromb Vasc Biol. 2005. PMID: 16051882 Clinical Trial.
Rheumatoid arthritis is associated with increased aortic pulse-wave velocity, which is reduced by anti-tumor necrosis factor-alpha therapy.
Mäki-Petäjä KM, Hall FC, Booth AD, Wallace SM, Yasmin, Bearcroft PW, Harish S, Furlong A, McEniery CM, Brown J, Wilkinson IB. Mäki-Petäjä KM, et al. Among authors: wilkinson ib. Circulation. 2006 Sep 12;114(11):1185-92. doi: 10.1161/CIRCULATIONAHA.105.601641. Epub 2006 Sep 4. Circulation. 2006. PMID: 16952987 Clinical Trial.
Simvastatin prevents inflammation-induced aortic stiffening and endothelial dysfunction.
Wallace SM, Mäki-Petäjä KM, Cheriyan J, Davidson EH, Cherry L, McEniery CM, Sattar N, Wilkinson IB, Kharbanda RK. Wallace SM, et al. Among authors: wilkinson ib. Br J Clin Pharmacol. 2010 Dec;70(6):799-806. doi: 10.1111/j.1365-2125.2010.03745.x. Br J Clin Pharmacol. 2010. PMID: 21175435 Free PMC article. Clinical Trial.
308 results