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The oxidoreductase PYROXD1 uses NAD(P)+ as an antioxidant to sustain tRNA ligase activity in pre-tRNA splicing and unfolded protein response.
Asanović I, Strandback E, Kroupova A, Pasajlic D, Meinhart A, Tsung-Pin P, Djokovic N, Anrather D, Schuetz T, Suskiewicz MJ, Sillamaa S, Köcher T, Beveridge R, Nikolic K, Schleiffer A, Jinek M, Hartl M, Clausen T, Penninger J, Macheroux P, Weitzer S, Martinez J. Asanović I, et al. Among authors: suskiewicz mj. Mol Cell. 2021 Jun 17;81(12):2520-2532.e16. doi: 10.1016/j.molcel.2021.04.007. Epub 2021 Apr 29. Mol Cell. 2021. PMID: 33930333 Free article.
Structural basis for the disaggregase activity and regulation of Hsp104.
Heuck A, Schitter-Sollner S, Suskiewicz MJ, Kurzbauer R, Kley J, Schleiffer A, Rombaut P, Herzog F, Clausen T. Heuck A, et al. Among authors: suskiewicz mj. Elife. 2016 Nov 30;5:e21516. doi: 10.7554/eLife.21516. Elife. 2016. PMID: 27901467 Free PMC article.
Structure of McsB, a protein kinase for regulated arginine phosphorylation.
Suskiewicz MJ, Hajdusits B, Beveridge R, Heuck A, Vu LD, Kurzbauer R, Hauer K, Thoeny V, Rumpel K, Mechtler K, Meinhart A, Clausen T. Suskiewicz MJ, et al. Nat Chem Biol. 2019 May;15(5):510-518. doi: 10.1038/s41589-019-0265-y. Epub 2019 Apr 8. Nat Chem Biol. 2019. PMID: 30962626 Free PMC article.
Unrestrained poly-ADP-ribosylation provides insights into chromatin regulation and human disease.
Prokhorova E, Agnew T, Wondisford AR, Tellier M, Kaminski N, Beijer D, Holder J, Groslambert J, Suskiewicz MJ, Zhu K, Reber JM, Krassnig SC, Palazzo L, Murphy S, Nielsen ML, Mangerich A, Ahel D, Baets J, O'Sullivan RJ, Ahel I. Prokhorova E, et al. Among authors: suskiewicz mj. Mol Cell. 2021 Jun 17;81(12):2640-2655.e8. doi: 10.1016/j.molcel.2021.04.028. Epub 2021 May 20. Mol Cell. 2021. PMID: 34019811 Free PMC article.
HPF1 completes the PARP active site for DNA damage-induced ADP-ribosylation.
Suskiewicz MJ, Zobel F, Ogden TEH, Fontana P, Ariza A, Yang JC, Zhu K, Bracken L, Hawthorne WJ, Ahel D, Neuhaus D, Ahel I. Suskiewicz MJ, et al. Nature. 2020 Mar;579(7800):598-602. doi: 10.1038/s41586-020-2013-6. Epub 2020 Feb 6. Nature. 2020. PMID: 32028527 Free PMC article.
Bridging of DNA breaks activates PARP2-HPF1 to modify chromatin.
Bilokapic S, Suskiewicz MJ, Ahel I, Halic M. Bilokapic S, et al. Among authors: suskiewicz mj. Nature. 2020 Sep;585(7826):609-613. doi: 10.1038/s41586-020-2725-7. Epub 2020 Sep 16. Nature. 2020. PMID: 32939087 Free PMC article.
24 results