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The oxidoreductase PYROXD1 uses NAD(P)+ as an antioxidant to sustain tRNA ligase activity in pre-tRNA splicing and unfolded protein response.
Asanović I, Strandback E, Kroupova A, Pasajlic D, Meinhart A, Tsung-Pin P, Djokovic N, Anrather D, Schuetz T, Suskiewicz MJ, Sillamaa S, Köcher T, Beveridge R, Nikolic K, Schleiffer A, Jinek M, Hartl M, Clausen T, Penninger J, Macheroux P, Weitzer S, Martinez J. Asanović I, et al. Among authors: schleiffer a. Mol Cell. 2021 Jun 17;81(12):2520-2532.e16. doi: 10.1016/j.molcel.2021.04.007. Epub 2021 Apr 29. Mol Cell. 2021. PMID: 33930333 Free article.
HSPC117 is the essential subunit of a human tRNA splicing ligase complex.
Popow J, Englert M, Weitzer S, Schleiffer A, Mierzwa B, Mechtler K, Trowitzsch S, Will CL, Lührmann R, Söll D, Martinez J. Popow J, et al. Among authors: schleiffer a. Science. 2011 Feb 11;331(6018):760-4. doi: 10.1126/science.1197847. Science. 2011. PMID: 21311021
Diversity and roles of (t)RNA ligases.
Popow J, Schleiffer A, Martinez J. Popow J, et al. Among authors: schleiffer a. Cell Mol Life Sci. 2012 Aug;69(16):2657-70. doi: 10.1007/s00018-012-0944-2. Epub 2012 Mar 17. Cell Mol Life Sci. 2012. PMID: 22426497 Free PMC article. Review.
Structural basis for the disaggregase activity and regulation of Hsp104.
Heuck A, Schitter-Sollner S, Suskiewicz MJ, Kurzbauer R, Kley J, Schleiffer A, Rombaut P, Herzog F, Clausen T. Heuck A, et al. Among authors: schleiffer a. Elife. 2016 Nov 30;5:e21516. doi: 10.7554/eLife.21516. Elife. 2016. PMID: 27901467 Free PMC article.
81 results