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The oxidoreductase PYROXD1 uses NAD(P)+ as an antioxidant to sustain tRNA ligase activity in pre-tRNA splicing and unfolded protein response.
Asanović I, Strandback E, Kroupova A, Pasajlic D, Meinhart A, Tsung-Pin P, Djokovic N, Anrather D, Schuetz T, Suskiewicz MJ, Sillamaa S, Köcher T, Beveridge R, Nikolic K, Schleiffer A, Jinek M, Hartl M, Clausen T, Penninger J, Macheroux P, Weitzer S, Martinez J. Asanović I, et al. Among authors: meinhart a. Mol Cell. 2021 Jun 17;81(12):2520-2532.e16. doi: 10.1016/j.molcel.2021.04.007. Epub 2021 Apr 29. Mol Cell. 2021. PMID: 33930333 Free article.
Structure of McsB, a protein kinase for regulated arginine phosphorylation.
Suskiewicz MJ, Hajdusits B, Beveridge R, Heuck A, Vu LD, Kurzbauer R, Hauer K, Thoeny V, Rumpel K, Mechtler K, Meinhart A, Clausen T. Suskiewicz MJ, et al. Among authors: meinhart a. Nat Chem Biol. 2019 May;15(5):510-518. doi: 10.1038/s41589-019-0265-y. Epub 2019 Apr 8. Nat Chem Biol. 2019. PMID: 30962626 Free PMC article.
Native Mass Spectrometry Can Effectively Predict PROTAC Efficacy.
Beveridge R, Kessler D, Rumpel K, Ettmayer P, Meinhart A, Clausen T. Beveridge R, et al. Among authors: meinhart a. ACS Cent Sci. 2020 Jul 22;6(7):1223-1230. doi: 10.1021/acscentsci.0c00049. Epub 2020 Jul 6. ACS Cent Sci. 2020. PMID: 32724856 Free PMC article.
BacPROTACs mediate targeted protein degradation in bacteria.
Morreale FE, Kleine S, Leodolter J, Junker S, Hoi DM, Ovchinnikov S, Okun A, Kley J, Kurzbauer R, Junk L, Guha S, Podlesainski D, Kazmaier U, Boehmelt G, Weinstabl H, Rumpel K, Schmiedel VM, Hartl M, Haselbach D, Meinhart A, Kaiser M, Clausen T. Morreale FE, et al. Among authors: meinhart a. Cell. 2022 Jun 23;185(13):2338-2353.e18. doi: 10.1016/j.cell.2022.05.009. Epub 2022 Jun 3. Cell. 2022. PMID: 35662409 Free PMC article.
HUWE1 employs a giant substrate-binding ring to feed and regulate its HECT E3 domain.
Grabarczyk DB, Petrova OA, Deszcz L, Kurzbauer R, Murphy P, Ahel J, Vogel A, Gogova R, Faas V, Kordic D, Schleiffer A, Meinhart A, Imre R, Lehner A, Neuhold J, Bader G, Stolt-Bergner P, Böttcher J, Wolkerstorfer B, Fischer G, Grishkovskaya I, Haselbach D, Kessler D, Clausen T. Grabarczyk DB, et al. Among authors: meinhart a. Nat Chem Biol. 2021 Oct;17(10):1084-1092. doi: 10.1038/s41589-021-00831-5. Epub 2021 Jul 22. Nat Chem Biol. 2021. PMID: 34294896 Free PMC article.
74 results