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The oxidoreductase PYROXD1 uses NAD(P)+ as an antioxidant to sustain tRNA ligase activity in pre-tRNA splicing and unfolded protein response.
Asanović I, Strandback E, Kroupova A, Pasajlic D, Meinhart A, Tsung-Pin P, Djokovic N, Anrather D, Schuetz T, Suskiewicz MJ, Sillamaa S, Köcher T, Beveridge R, Nikolic K, Schleiffer A, Jinek M, Hartl M, Clausen T, Penninger J, Macheroux P, Weitzer S, Martinez J. Asanović I, et al. Among authors: kroupova a. Mol Cell. 2021 Jun 17;81(12):2520-2532.e16. doi: 10.1016/j.molcel.2021.04.007. Epub 2021 Apr 29. Mol Cell. 2021. PMID: 33930333 Free article.
Molecular architecture of the human tRNA ligase complex.
Kroupova A, Ackle F, Asanović I, Weitzer S, Boneberg FM, Faini M, Leitner A, Chui A, Aebersold R, Martinez J, Jinek M. Kroupova A, et al. Elife. 2021 Dec 2;10:e71656. doi: 10.7554/eLife.71656. Elife. 2021. PMID: 34854379 Free PMC article.
Design of a Cereblon construct for crystallographic and biophysical studies of protein degraders.
Kroupova A, Spiteri VA, Rutter ZJ, Furihata H, Darren D, Ramachandran S, Chakraborti S, Haubrich K, Pethe J, Gonzales D, Wijaya AJ, Rodriguez-Rios M, Sturbaut M, Lynch DM, Farnaby W, Nakasone MA, Zollman D, Ciulli A. Kroupova A, et al. Nat Commun. 2024 Oct 15;15(1):8885. doi: 10.1038/s41467-024-52871-9. Nat Commun. 2024. PMID: 39406745 Free PMC article.