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The oxidoreductase PYROXD1 uses NAD(P)+ as an antioxidant to sustain tRNA ligase activity in pre-tRNA splicing and unfolded protein response.
Asanović I, Strandback E, Kroupova A, Pasajlic D, Meinhart A, Tsung-Pin P, Djokovic N, Anrather D, Schuetz T, Suskiewicz MJ, Sillamaa S, Köcher T, Beveridge R, Nikolic K, Schleiffer A, Jinek M, Hartl M, Clausen T, Penninger J, Macheroux P, Weitzer S, Martinez J. Asanović I, et al. Among authors: kocher t. Mol Cell. 2021 Jun 17;81(12):2520-2532.e16. doi: 10.1016/j.molcel.2021.04.007. Epub 2021 Apr 29. Mol Cell. 2021. PMID: 33930333 Free article.
AIF-regulated oxidative phosphorylation supports lung cancer development.
Rao S, Mondragón L, Pranjic B, Hanada T, Stoll G, Köcher T, Zhang P, Jais A, Lercher A, Bergthaler A, Schramek D, Haigh K, Sica V, Leduc M, Modjtahedi N, Pai TP, Onji M, Uribesalgo I, Hanada R, Kozieradzki I, Koglgruber R, Cronin SJ, She Z, Quehenberger F, Popper H, Kenner L, Haigh JJ, Kepp O, Rak M, Cai K, Kroemer G, Penninger JM. Rao S, et al. Among authors: kocher t. Cell Res. 2019 Jul;29(7):579-591. doi: 10.1038/s41422-019-0181-4. Epub 2019 May 27. Cell Res. 2019. PMID: 31133695 Free PMC article.
Multiplexed detection of SARS-CoV-2 and other respiratory infections in high throughput by SARSeq.
Yelagandula R, Bykov A, Vogt A, Heinen R, Özkan E, Strobl MM, Baar JC, Uzunova K, Hajdusits B, Kordic D, Suljic E, Kurtovic-Kozaric A, Izetbegovic S, Schaeffer J, Hufnagl P, Zoufaly A, Seitz T; VCDI; Födinger M, Allerberger F, Stark A, Cochella L, Elling U. Yelagandula R, et al. Nat Commun. 2021 May 25;12(1):3132. doi: 10.1038/s41467-021-22664-5. Nat Commun. 2021. PMID: 34035246 Free PMC article.
Mast cell-derived BH4 and serotonin are critical mediators of postoperative pain.
Starkl P, Jonsson G, Artner T, Turnes BL, Gail LM, Oliveira T, Jain A, Serhan N, Stejskal K, Lakovits K, Hladik A, An M, Channon KM, Kim H, Köcher T, Weninger W, Stary G, Knapp S, Klang V, Gaudenzio N, Woolf CJ, Tikoo S, Jain R, Penninger JM, Cronin SJF. Starkl P, et al. Among authors: kocher t. Sci Immunol. 2024 Aug 23;9(98):eadh0545. doi: 10.1126/sciimmunol.adh0545. Epub 2024 Aug 23. Sci Immunol. 2024. PMID: 39178277
Kynurenine importation by SLC7A11 propagates anti-ferroptotic signaling.
Fiore A, Zeitler L, Russier M, Groß A, Hiller MK, Parker JL, Stier L, Köcher T, Newstead S, Murray PJ. Fiore A, et al. Among authors: kocher t. Mol Cell. 2022 Mar 3;82(5):920-932.e7. doi: 10.1016/j.molcel.2022.02.007. Mol Cell. 2022. PMID: 35245456 Free article.
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