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Early administration of amatuximab, a chimeric high-affinity anti-mesothelin monoclonal antibody, suppresses liver metastasis of mesothelin-expressing pancreatic cancer cells and enhances gemcitabine sensitivity in a xenograft mouse model.
Fujii Y, Kamachi H, Matsuzawa F, Mizukami T, Kobayashi N, Fukai M, Taketomi A. Fujii Y, et al. Among authors: mizukami t. Invest New Drugs. 2021 Oct;39(5):1256-1266. doi: 10.1007/s10637-021-01118-1. Epub 2021 Apr 27. Invest New Drugs. 2021. PMID: 33905019
The anti-mesothelin monoclonal antibody amatuximab enhances the anti-tumor effect of gemcitabine against mesothelin-high expressing pancreatic cancer cells in a peritoneal metastasis mouse model.
Mizukami T, Kamachi H, Fujii Y, Matsuzawa F, Einama T, Kawamata F, Kobayashi N, Hatanaka Y, Taketomi A. Mizukami T, et al. Oncotarget. 2018 Sep 18;9(73):33844-33852. doi: 10.18632/oncotarget.26117. eCollection 2018 Sep 18. Oncotarget. 2018. PMID: 30333914 Free PMC article.
Mesothelin blockage by Amatuximab suppresses cell invasiveness, enhances gemcitabine sensitivity and regulates cancer cell stemness in mesothelin-positive pancreatic cancer cells.
Matsuzawa F, Kamachi H, Mizukami T, Einama T, Kawamata F, Fujii Y, Fukai M, Kobayashi N, Hatanaka Y, Taketomi A. Matsuzawa F, et al. Among authors: mizukami t. BMC Cancer. 2021 Feb 26;21(1):200. doi: 10.1186/s12885-020-07722-3. BMC Cancer. 2021. PMID: 33637083 Free PMC article.
Clinical impacts of mesothelin expression in gastrointestinal carcinomas.
Einama T, Kawamata F, Kamachi H, Nishihara H, Homma S, Matsuzawa F, Mizukami T, Konishi Y, Tahara M, Kamiyama T, Hino O, Taketomi A, Todo S. Einama T, et al. Among authors: mizukami t. World J Gastrointest Pathophysiol. 2016 May 15;7(2):218-22. doi: 10.4291/wjgp.v7.i2.218. World J Gastrointest Pathophysiol. 2016. PMID: 27190694 Free PMC article. Review.
The incidence of cardiovascular thrombotic complications after laparoscopic resection in colorectal cancer in Japanese hospitals: A large-scale clinical study.
Ichikawa N, Homma S, Funakoshi T, Obuchi K, Ohshima T, Uemura K, Kon H, Ohno Y, Yokota R, Taketomi A; Hokkaido Colorectal Surgical Research Group Collaborative. Ichikawa N, et al. Ann Gastroenterol Surg. 2021 Dec 12;6(3):396-404. doi: 10.1002/ags3.12531. eCollection 2022 May. Ann Gastroenterol Surg. 2021. PMID: 35634183 Free PMC article.
569 results