Haskell-Luevano C - Search Results

1

Discovery of Nanomolar Melanocortin-3 Receptor (MC3R)-Selective Small Molecule Pyrrolidine Bis-Cyclic Guanidine Agonist Compounds Via a High-Throughput "Unbiased" Screening Campaign.

Doering SR, Freeman K, Debevec G, Geer P, Santos RG, Lavoi TM, Giulianotti MA, Pinilla C, Appel JR, Houghten RA, Ericson MD, Haskell-Luevano C. Doering SR, et al. J Med Chem. 2021 May 13;64(9):5577-5592. doi: 10.1021/acs.jmedchem.0c02041. Epub 2021 Apr 22. J Med Chem. 2021. PMID: 33886285 Free PMC article.

2

Topographical modification of melanotropin peptide analogues with beta-methyltryptophan isomers at position 9 leads to differential potencies and prolonged biological activities.

Haskell-Luevano C, Boteju LW, Miwa H, Dickinson C, Gantz I, Yamada T, Hadley ME, Hruby VJ. Haskell-Luevano C, et al. J Med Chem. 1995 Nov 10;38(23):4720-9. doi: 10.1021/jm00023a012. J Med Chem. 1995. PMID: 7473600

3

Characterizations of the unusual dissociation properties of melanotropin peptides from the melanocortin receptor, hMC1R.

Haskell-Luevano C, Miwa H, Dickinson C, Hadley ME, Hruby VJ, Yamada T, Gantz I. Haskell-Luevano C, et al. J Med Chem. 1996 Jan 19;39(2):432-5. doi: 10.1021/jm950407s. J Med Chem. 1996. PMID: 8558511

4

Discovery of prototype peptidomimetic agonists at the human melanocortin receptors MC1R and MC4R.

Haskell-Luevano C, Hendrata S, North C, Sawyer TK, Hadley ME, Hruby VJ, Dickinson C, Gantz I. Haskell-Luevano C, et al. J Med Chem. 1997 Jul 4;40(14):2133-9. doi: 10.1021/jm960840h. J Med Chem. 1997. PMID: 9216831

5

Compounds that activate the mouse melanocortin-1 receptor identified by screening a small molecule library based upon the beta-turn.

Haskell-Luevano C, Rosenquist A, Souers A, Khong KC, Ellman JA, Cone RD. Haskell-Luevano C, et al. J Med Chem. 1999 Oct 21;42(21):4380-7. doi: 10.1021/jm990190s. J Med Chem. 1999. PMID: 10543881

6

Characterization of melanocortin NDP-MSH agonist peptide fragments at the mouse central and peripheral melanocortin receptors.

Haskell-Luevano C, Holder JR, Monck EK, Bauzo RM. Haskell-Luevano C, et al. J Med Chem. 2001 Jun 21;44(13):2247-52. doi: 10.1021/jm010061n. J Med Chem. 2001. PMID: 11405661

7

Novel agouti-related-protein-based melanocortin-1 receptor antagonist.

Thirumoorthy R, Holder JR, Bauzo RM, Richards NG, Edison AS, Haskell-Luevano C. Thirumoorthy R, et al. J Med Chem. 2001 Nov 22;44(24):4114-24. doi: 10.1021/jm010215z. J Med Chem. 2001. PMID: 11708914

8

Structure-activity relationships of the melanocortin tetrapeptide Ac-His-DPhe-Arg-Trp-NH(2) at the mouse melanocortin receptors. 1. Modifications at the His position.

Holder JR, Bauzo RM, Xiang Z, Haskell-Luevano C. Holder JR, et al. J Med Chem. 2002 Jun 20;45(13):2801-10. doi: 10.1021/jm0104872. J Med Chem. 2002. PMID: 12061882

9

Structure-activity relationships of the melanocortin tetrapeptide Ac-His-DPhe-Arg-Trp-NH(2) at the mouse melanocortin receptors: part 2 modifications at the Phe position.

Holder JR, Bauzo RM, Xiang Z, Haskell-Luevano C. Holder JR, et al. J Med Chem. 2002 Jul 4;45(14):3073-81. doi: 10.1021/jm010524p. J Med Chem. 2002. PMID: 12086493

10

Structure-activity relationships of the melanocortin tetrapeptide Ac-His-D-Phe-Arg-Trp-NH2 at the mouse melanocortin receptors. 4. Modifications at the Trp position.

Holder JR, Xiang Z, Bauzo RM, Haskell-Luevano C. Holder JR, et al. J Med Chem. 2002 Dec 19;45(26):5736-44. doi: 10.1021/jm020296e. J Med Chem. 2002. PMID: 12477357

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