Ditano JP - Search Results

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Comparative Activity and Off-Target Effects in Cells of the CHK1 Inhibitors MK-8776, SRA737, and LY2606368.

Ditano JP, Eastman A. Ditano JP, et al. ACS Pharmacol Transl Sci. 2021 Feb 12;4(2):730-743. doi: 10.1021/acsptsci.0c00201. eCollection 2021 Apr 9. ACS Pharmacol Transl Sci. 2021. PMID: 33860197 Free PMC article.

Sensitivity of cells to ATR and CHK1 inhibitors requires hyperactivation of CDK2 rather than endogenous replication stress or ATM dysfunction.

Ditano JP, Donahue KL, Tafe LJ, McCleery CF, Eastman A. Ditano JP, et al. Sci Rep. 2021 Mar 29;11(1):7077. doi: 10.1038/s41598-021-86490-x. Sci Rep. 2021. PMID: 33782497 Free PMC article.

Inhibition of Protein Synthesis Induced by CHK1 Inhibitors Discriminates Sensitive from Resistant Cancer Cells.

Hinds JW, Ditano JP, Eastman A. Hinds JW, et al. Among authors: ditano jp. ACS Pharmacol Transl Sci. 2021 Aug 4;4(4):1449-1461. doi: 10.1021/acsptsci.1c00150. eCollection 2021 Aug 13. ACS Pharmacol Transl Sci. 2021. PMID: 34423276 Free PMC article.

Activation of CDC25A phosphatase is limited by CDK2/cyclin A-mediated feedback inhibition.

Ditano JP, Sakurikar N, Eastman A. Ditano JP, et al. Cell Cycle. 2021 Jul;20(13):1308-1319. doi: 10.1080/15384101.2021.1938813. Epub 2021 Jun 22. Cell Cycle. 2021. PMID: 34156324 Free PMC article.

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