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Glucocorticoids and B Cell Depleting Agents Substantially Impair Immunogenicity of mRNA Vaccines to SARS-CoV-2.
Deepak P, Kim W, Paley MA, Yang M, Carvidi AB, El-Qunni AA, Haile A, Huang K, Kinnett B, Liebeskind MJ, Liu Z, McMorrow LE, Paez D, Perantie DC, Schriefer RE, Sides SE, Thapa M, Gergely M, Abushamma S, Klebert M, Mitchell L, Nix D, Graf J, Taylor KE, Chahin S, Ciorba MA, Katz P, Matloubian M, O'Halloran JA, Presti RM, Wu GF, Whelan SPJ, Buchser WJ, Gensler LS, Nakamura MC, Ellebedy AH, Kim AHJ. Deepak P, et al. Among authors: liu z. medRxiv [Preprint]. 2021 Apr 9:2021.04.05.21254656. doi: 10.1101/2021.04.05.21254656. medRxiv. 2021. Update in: Ann Intern Med. 2021 Nov;174(11):1572-1585. doi: 10.7326/M21-1757 PMID: 33851176 Free PMC article. Updated. Preprint.
TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes.
Zang R, Gomez Castro MF, McCune BT, Zeng Q, Rothlauf PW, Sonnek NM, Liu Z, Brulois KF, Wang X, Greenberg HB, Diamond MS, Ciorba MA, Whelan SPJ, Ding S. Zang R, et al. Among authors: liu z. Sci Immunol. 2020 May 13;5(47):eabc3582. doi: 10.1126/sciimmunol.abc3582. Sci Immunol. 2020. PMID: 32404436 Free PMC article.
Inhibition of PIKfyve kinase prevents infection by Zaire ebolavirus and SARS-CoV-2.
Kang YL, Chou YY, Rothlauf PW, Liu Z, Soh TK, Cureton D, Case JB, Chen RE, Diamond MS, Whelan SPJ, Kirchhausen T. Kang YL, et al. Among authors: liu z. bioRxiv [Preprint]. 2020 Jun 15:2020.04.21.053058. doi: 10.1101/2020.04.21.053058. bioRxiv. 2020. Update in: Proc Natl Acad Sci U S A. 2020 Aug 25;117(34):20803-20813. doi: 10.1073/pnas.2007837117 PMID: 32511398 Free PMC article. Updated. Preprint.
Neutralizing antibody and soluble ACE2 inhibition of a replication-competent VSV-SARS-CoV-2 and a clinical isolate of SARS-CoV-2.
Case JB, Rothlauf PW, Chen RE, Liu Z, Zhao H, Kim AS, Bloyet LM, Zeng Q, Tahan S, Droit L, Ilagan MXG, Tartell MA, Amarasinghe G, Henderson JP, Miersch S, Ustav M, Sidhu S, Virgin HW, Wang D, Ding S, Corti D, Theel ES, Fremont DH, Diamond MS, Whelan SPJ. Case JB, et al. Among authors: liu z. bioRxiv [Preprint]. 2020 May 18:2020.05.18.102038. doi: 10.1101/2020.05.18.102038. bioRxiv. 2020. Update in: Cell Host Microbe. 2020 Sep 9;28(3):475-485.e5. doi: 10.1016/j.chom.2020.06.021 PMID: 32511401 Free PMC article. Updated. Preprint.
Neutralizing antibody and soluble ACE2 inhibition of a replication-competent VSV-SARS-CoV-2 and a clinical isolate of SARS-CoV-2.
Case JB, Rothlauf PW, Chen RE, Liu Z, Zhao H, Kim AS, Bloyet LM, Zeng Q, Tahan S, Droit L, Ilagan MXG, Tartell MA, Amarasinghe G, Henderson JP, Miersch S, Ustav M, Sidhu S, Virgin HW, Wang D, Ding S, Corti D, Theel ES, Fremont DH, Diamond MS, Whelan SPJ. Case JB, et al. Among authors: liu z. SSRN [Preprint]. 2020 May 27:3606354. doi: 10.2139/ssrn.3606354. SSRN. 2020. Update in: Cell Host Microbe. 2020 Sep 9;28(3):475-485.e5. doi: 10.1016/j.chom.2020.06.021 PMID: 32714117 Free PMC article. Updated. Preprint.
Neutralizing Antibody and Soluble ACE2 Inhibition of a Replication-Competent VSV-SARS-CoV-2 and a Clinical Isolate of SARS-CoV-2.
Case JB, Rothlauf PW, Chen RE, Liu Z, Zhao H, Kim AS, Bloyet LM, Zeng Q, Tahan S, Droit L, Ilagan MXG, Tartell MA, Amarasinghe G, Henderson JP, Miersch S, Ustav M, Sidhu S, Virgin HW, Wang D, Ding S, Corti D, Theel ES, Fremont DH, Diamond MS, Whelan SPJ. Case JB, et al. Among authors: liu z. Cell Host Microbe. 2020 Sep 9;28(3):475-485.e5. doi: 10.1016/j.chom.2020.06.021. Epub 2020 Jul 3. Cell Host Microbe. 2020. PMID: 32735849 Free PMC article.
Inhibition of PIKfyve kinase prevents infection by Zaire ebolavirus and SARS-CoV-2.
Kang YL, Chou YY, Rothlauf PW, Liu Z, Soh TK, Cureton D, Case JB, Chen RE, Diamond MS, Whelan SPJ, Kirchhausen T. Kang YL, et al. Among authors: liu z. Proc Natl Acad Sci U S A. 2020 Aug 25;117(34):20803-20813. doi: 10.1073/pnas.2007837117. Epub 2020 Aug 6. Proc Natl Acad Sci U S A. 2020. PMID: 32764148 Free PMC article.
Complete mapping of mutations to the SARS-CoV-2 spike receptor-binding domain that escape antibody recognition.
Greaney AJ, Starr TN, Gilchuk P, Zost SJ, Binshtein E, Loes AN, Hilton SK, Huddleston J, Eguia R, Crawford KHD, Dingens AS, Nargi RS, Sutton RE, Suryadevara N, Rothlauf PW, Liu Z, Whelan SPJ, Carnahan RH, Crowe JE Jr, Bloom JD. Greaney AJ, et al. Among authors: liu z. bioRxiv [Preprint]. 2020 Sep 28:2020.09.10.292078. doi: 10.1101/2020.09.10.292078. bioRxiv. 2020. Update in: Cell Host Microbe. 2021 Jan 13;29(1):44-57.e9. doi: 10.1016/j.chom.2020.11.007 PMID: 32935107 Free PMC article. Updated. Preprint.
JIB-04 has broad-spectrum antiviral activity and inhibits SARS-CoV-2 replication and coronavirus pathogenesis.
Son J, Huang S, Zeng Q, Bricker TL, Case JB, Zhou J, Zang R, Liu Z, Chang X, Harastani HH, Chen L, Castro MFG, Zhao Y, Kohio HP, Hou G, Fan B, Niu B, Guo R, Rothlauf PW, Bailey AL, Wang X, Shi PY, Martinez ED, Whelan SPJ, Diamond MS, Boon ACM, Li B, Ding S. Son J, et al. Among authors: liu z. bioRxiv [Preprint]. 2021 Jun 4:2020.09.24.312165. doi: 10.1101/2020.09.24.312165. bioRxiv. 2021. Update in: mBio. 2022 Jan 18;13(1):e0337721. doi: 10.1128/mbio.03377-21 PMID: 32995798 Free PMC article. Updated. Preprint.
Landscape analysis of escape variants identifies SARS-CoV-2 spike mutations that attenuate monoclonal and serum antibody neutralization.
Liu Z, VanBlargan LA, Bloyet LM, Rothlauf PW, Chen RE, Stumpf S, Zhao H, Errico JM, Theel ES, Liebeskind MJ, Alford B, Buchser WJ, Ellebedy AH, Fremont DH, Diamond MS, Whelan SPJ. Liu Z, et al. bioRxiv [Preprint]. 2021 Jan 11:2020.11.06.372037. doi: 10.1101/2020.11.06.372037. bioRxiv. 2021. Update in: Cell Host Microbe. 2021 Mar 10;29(3):477-488.e4. doi: 10.1016/j.chom.2021.01.014 PMID: 33442690 Free PMC article. Updated. Preprint.
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