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mTORC2 controls the activity of PKC and Akt by phosphorylating a conserved TOR interaction motif.
Baffi TR, Lordén G, Wozniak JM, Feichtner A, Yeung W, Kornev AP, King CC, Del Rio JC, Limaye AJ, Bogomolovas J, Gould CM, Chen J, Kennedy EJ, Kannan N, Gonzalez DJ, Stefan E, Taylor SS, Newton AC. Baffi TR, et al. Among authors: limaye aj. Sci Signal. 2021 Apr 13;14(678):eabe4509. doi: 10.1126/scisignal.abe4509. Sci Signal. 2021. PMID: 33850054 Free PMC article.
Targeted disruption of PKC from AKAP signaling complexes.
Limaye AJ, Bendzunas GN, Kennedy EJ. Limaye AJ, et al. RSC Chem Biol. 2021 Jul 19;2(4):1227-1231. doi: 10.1039/d1cb00106j. eCollection 2021 Aug 5. RSC Chem Biol. 2021. PMID: 34458835 Free PMC article.
In Silico Optimized Stapled Peptides Targeting WASF3 in Breast Cancer.
Limaye AJ, Bendzunas GN, Whittaker MK, LeClair TJ, Helton LG, Kennedy EJ. Limaye AJ, et al. ACS Med Chem Lett. 2022 Mar 8;13(4):570-576. doi: 10.1021/acsmedchemlett.1c00627. eCollection 2022 Apr 14. ACS Med Chem Lett. 2022. PMID: 35450347 Free PMC article.
Targeting the WASF3 complex to suppress metastasis.
Limaye AJ, Whittaker MK, Bendzunas GN, Cowell JK, Kennedy EJ. Limaye AJ, et al. Pharmacol Res. 2022 Aug;182:106302. doi: 10.1016/j.phrs.2022.106302. Epub 2022 Jun 9. Pharmacol Res. 2022. PMID: 35691539 Review.