Kannan N - Search Results

1

mTORC2 controls the activity of PKC and Akt by phosphorylating a conserved TOR interaction motif.

Baffi TR, Lordén G, Wozniak JM, Feichtner A, Yeung W, Kornev AP, King CC, Del Rio JC, Limaye AJ, Bogomolovas J, Gould CM, Chen J, Kennedy EJ, Kannan N, Gonzalez DJ, Stefan E, Taylor SS, Newton AC. Baffi TR, et al. Among authors: kannan n. Sci Signal. 2021 Apr 13;14(678):eabe4509. doi: 10.1126/scisignal.abe4509. Sci Signal. 2021. PMID: 33850054 Free PMC article.

2

Crystal structure of the E230Q mutant of cAMP-dependent protein kinase reveals an unexpected apoenzyme conformation and an extended N-terminal A helix.

Wu J, Yang J, Kannan N, Madhusudan, Xuong NH, Ten Eyck LF, Taylor SS. Wu J, et al. Among authors: kannan n. Protein Sci. 2005 Nov;14(11):2871-9. doi: 10.1110/ps.051715205. Protein Sci. 2005. PMID: 16253959 Free PMC article.

3

The hallmark of AGC kinase functional divergence is its C-terminal tail, a cis-acting regulatory module.

Kannan N, Haste N, Taylor SS, Neuwald AF. Kannan N, et al. Proc Natl Acad Sci U S A. 2007 Jan 23;104(4):1272-7. doi: 10.1073/pnas.0610251104. Epub 2007 Jan 16. Proc Natl Acad Sci U S A. 2007. PMID: 17227859 Free PMC article.

4

Structural and functional diversity of the microbial kinome.

Kannan N, Taylor SS, Zhai Y, Venter JC, Manning G. Kannan N, et al. PLoS Biol. 2007 Mar;5(3):e17. doi: 10.1371/journal.pbio.0050017. PLoS Biol. 2007. PMID: 17355172 Free PMC article.

5

Analogous regulatory sites within the alphaC-beta4 loop regions of ZAP-70 tyrosine kinase and AGC kinases.

Kannan N, Neuwald AF, Taylor SS. Kannan N, et al. Biochim Biophys Acta. 2008 Jan;1784(1):27-32. doi: 10.1016/j.bbapap.2007.09.007. Epub 2007 Sep 29. Biochim Biophys Acta. 2008. PMID: 17977811 Free PMC article. Review.

6

Signaling through cAMP and cAMP-dependent protein kinase: diverse strategies for drug design.

Taylor SS, Kim C, Cheng CY, Brown SH, Wu J, Kannan N. Taylor SS, et al. Among authors: kannan n. Biochim Biophys Acta. 2008 Jan;1784(1):16-26. doi: 10.1016/j.bbapap.2007.10.002. Epub 2007 Oct 12. Biochim Biophys Acta. 2008. PMID: 17996741 Free PMC article. Review.

7

Evolution of allostery in the cyclic nucleotide binding module.

Kannan N, Wu J, Anand GS, Yooseph S, Neuwald AF, Venter JC, Taylor SS. Kannan N, et al. Genome Biol. 2007;8(12):R264. doi: 10.1186/gb-2007-8-12-r264. Genome Biol. 2007. PMID: 18076763 Free PMC article.

8

Rethinking pseudokinases.

Kannan N, Taylor SS. Kannan N, et al. Cell. 2008 Apr 18;133(2):204-5. doi: 10.1016/j.cell.2008.04.005. Cell. 2008. PMID: 18423189 Free PMC article.

9

Congenital disease SNPs target lineage specific structural elements in protein kinases.

Torkamani A, Kannan N, Taylor SS, Schork NJ. Torkamani A, et al. Among authors: kannan n. Proc Natl Acad Sci U S A. 2008 Jul 1;105(26):9011-6. doi: 10.1073/pnas.0802403105. Epub 2008 Jun 25. Proc Natl Acad Sci U S A. 2008. PMID: 18579784 Free PMC article.

10

The chaperones Hsp90 and Cdc37 mediate the maturation and stabilization of protein kinase C through a conserved PXXP motif in the C-terminal tail.

Gould CM, Kannan N, Taylor SS, Newton AC. Gould CM, et al. Among authors: kannan n. J Biol Chem. 2009 Feb 20;284(8):4921-35. doi: 10.1074/jbc.M808436200. Epub 2008 Dec 17. J Biol Chem. 2009. PMID: 19091746 Free PMC article.

Here we show that a conserved PXXP motif (Kannan, N., Haste, N., Taylor, S. S., and Neuwald, A. F. (2007) Proc. Natl. Acad. Sci. ...

Here we show that a conserved PXXP motif (Kannan, N., Haste, N., Taylor, S. S., and Neuwald, A. F. (2007) Proc. Natl. A …

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