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Discovery of multifunctional anti-Alzheimer's agents with a unique mechanism of action including inhibition of the enzyme butyrylcholinesterase and γ-aminobutyric acid transporters.
Pasieka A, Panek D, Jończyk J, Godyń J, Szałaj N, Latacz G, Tabor J, Mezeiova E, Chantegreil F, Dias J, Knez D, Lu J, Pi R, Korabecny J, Brazzolotto X, Gobec S, Höfner G, Wanner K, Więckowska A, Malawska B. Pasieka A, et al. Among authors: knez d. Eur J Med Chem. 2021 Jun 5;218:113397. doi: 10.1016/j.ejmech.2021.113397. Epub 2021 Mar 31. Eur J Med Chem. 2021. PMID: 33838585
Synthesis and Biological Assessment of Racemic Benzochromenopyrimidinimines as Antioxidant, Cholinesterase, and Aβ1-42 Aggregation Inhibitors for Alzheimer's Disease Therapy.
Dgachi Y, Ismaili L, Knez D, Benchekroun M, Martin H, Szałaj N, Wehle S, Bautista-Aguilera OM, Luzet V, Bonnet A, Malawska B, Gobec S, Chioua M, Decker M, Chabchoub F, Marco-Contelles J. Dgachi Y, et al. Among authors: knez d. ChemMedChem. 2016 Jun 20;11(12):1318-27. doi: 10.1002/cmdc.201500539. Epub 2016 Jan 25. ChemMedChem. 2016. PMID: 26804623
Synthesis and Biological Evaluation of Benzochromenopyrimidinones as Cholinesterase Inhibitors and Potent Antioxidant, Non-Hepatotoxic Agents for Alzheimer's Disease.
Dgachi Y, Bautista-Aguilera OM, Benchekroun M, Martin H, Bonet A, Knez D, Godyń J, Malawska B, Gobec S, Chioua M, Janockova J, Soukup O, Chabchoub F, Marco-Contelles J, Ismaili L. Dgachi Y, et al. Among authors: knez d. Molecules. 2016 May 14;21(5):634. doi: 10.3390/molecules21050634. Molecules. 2016. PMID: 27187348 Free PMC article.
113 results