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Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia.
Wang C, Xiong M, Gratuze M, Bao X, Shi Y, Andhey PS, Manis M, Schroeder C, Yin Z, Madore C, Butovsky O, Artyomov M, Ulrich JD, Holtzman DM. Wang C, et al. Among authors: gratuze m. Neuron. 2021 May 19;109(10):1657-1674.e7. doi: 10.1016/j.neuron.2021.03.024. Epub 2021 Apr 7. Neuron. 2021. PMID: 33831349 Free PMC article.
TREM2 function impedes tau seeding in neuritic plaques.
Leyns CEG, Gratuze M, Narasimhan S, Jain N, Koscal LJ, Jiang H, Manis M, Colonna M, Lee VMY, Ulrich JD, Holtzman DM. Leyns CEG, et al. Among authors: gratuze m. Nat Neurosci. 2019 Aug;22(8):1217-1222. doi: 10.1038/s41593-019-0433-0. Epub 2019 Jun 24. Nat Neurosci. 2019. PMID: 31235932 Free PMC article.
Tau, Diabetes and Insulin.
Gratuze M, Joly-Amado A, Buee L, Vieau D, Blum D. Gratuze M, et al. Adv Exp Med Biol. 2019;1184:259-287. doi: 10.1007/978-981-32-9358-8_21. Adv Exp Med Biol. 2019. PMID: 32096044 Review.
SEQUIN Multiscale Imaging of Mammalian Central Synapses Reveals Loss of Synaptic Connectivity Resulting from Diffuse Traumatic Brain Injury.
Sauerbeck AD, Gangolli M, Reitz SJ, Salyards MH, Kim SH, Hemingway C, Gratuze M, Makkapati T, Kerschensteiner M, Holtzman DM, Brody DL, Kummer TT. Sauerbeck AD, et al. Among authors: gratuze m. Neuron. 2020 Jul 22;107(2):257-273.e5. doi: 10.1016/j.neuron.2020.04.012. Epub 2020 May 8. Neuron. 2020. PMID: 32392471 Free PMC article.
Activated microglia mitigate Aβ-associated tau seeding and spreading.
Gratuze M, Chen Y, Parhizkar S, Jain N, Strickland MR, Serrano JR, Colonna M, Ulrich JD, Holtzman DM. Gratuze M, et al. J Exp Med. 2021 Aug 2;218(8):e20210542. doi: 10.1084/jem.20210542. Epub 2021 Jun 8. J Exp Med. 2021. PMID: 34100905 Free PMC article.
40 results