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Elicitation of potent serum neutralizing antibody responses in rabbits by immunization with an HIV-1 clade C trimeric Env derived from an Indian elite neutralizer.
Kumar R, Deshpande S, Sewall LM, Ozorowski G, Cottrell CA, Lee WH, Holden LG, Richey ST, Chandrawacar AS, Dhiman K, Ashish, Kumar V, Ahmed S, Hingankar N, Kumar N, Murugavel KG, Srikrishnan AK, Sok D, Ward AB, Bhattacharya J. Kumar R, et al. Among authors: lee wh. PLoS Pathog. 2021 Apr 7;17(4):e1008977. doi: 10.1371/journal.ppat.1008977. eCollection 2021 Apr. PLoS Pathog. 2021. PMID: 33826683 Free PMC article.
Structure of the human volume regulated anion channel.
Kefauver JM, Saotome K, Dubin AE, Pallesen J, Cottrell CA, Cahalan SM, Qiu Z, Hong G, Crowley CS, Whitwam T, Lee WH, Ward AB, Patapoutian A. Kefauver JM, et al. Among authors: lee wh. Elife. 2018 Aug 10;7:e38461. doi: 10.7554/eLife.38461. Elife. 2018. PMID: 30095067 Free PMC article.
Stabilization of the V2 loop improves the presentation of V2 loop-associated broadly neutralizing antibody epitopes on HIV-1 envelope trimers.
de Taeye SW, Go EP, Sliepen K, de la Peña AT, Badal K, Medina-Ramírez M, Lee WH, Desaire H, Wilson IA, Moore JP, Ward AB, Sanders RW. de Taeye SW, et al. Among authors: lee wh. J Biol Chem. 2019 Apr 5;294(14):5616-5631. doi: 10.1074/jbc.RA118.005396. Epub 2019 Feb 6. J Biol Chem. 2019. PMID: 30728245 Free PMC article.
Developability Assessment of Physicochemical Properties and Stability Profiles of HIV-1 BG505 SOSIP.664 and BG505 SOSIP.v4.1-GT1.1 gp140 Envelope Glycoprotein Trimers as Candidate Vaccine Antigens.
Whitaker N, Hickey JM, Kaur K, Xiong J, Sawant N, Cupo A, Lee WH, Ozorowski G, Medina-Ramírez M, Ward AB, Sanders RW, Moore JP, Joshi SB, Volkin DB, Dey AK. Whitaker N, et al. Among authors: lee wh. J Pharm Sci. 2019 Jul;108(7):2264-2277. doi: 10.1016/j.xphs.2019.01.033. Epub 2019 Feb 15. J Pharm Sci. 2019. PMID: 30776383 Free PMC article.
Structures of the otopetrin proton channels Otop1 and Otop3.
Saotome K, Teng B, Tsui CCA, Lee WH, Tu YH, Kaplan JP, Sansom MSP, Liman ER, Ward AB. Saotome K, et al. Among authors: lee wh. Nat Struct Mol Biol. 2019 Jun;26(6):518-525. doi: 10.1038/s41594-019-0235-9. Epub 2019 Jun 3. Nat Struct Mol Biol. 2019. PMID: 31160780 Free PMC article.
HIV-1 Envelope and MPER Antibody Structures in Lipid Assemblies.
Rantalainen K, Berndsen ZT, Antanasijevic A, Schiffner T, Zhang X, Lee WH, Torres JL, Zhang L, Irimia A, Copps J, Zhou KH, Kwon YD, Law WH, Schramm CA, Verardi R, Krebs SJ, Kwong PD, Doria-Rose NA, Wilson IA, Zwick MB, Yates JR 3rd, Schief WR, Ward AB. Rantalainen K, et al. Among authors: lee wh. Cell Rep. 2020 Apr 28;31(4):107583. doi: 10.1016/j.celrep.2020.107583. Cell Rep. 2020. PMID: 32348769 Free PMC article.
Enhancing glycan occupancy of soluble HIV-1 envelope trimers to mimic the native viral spike.
Derking R, Allen JD, Cottrell CA, Sliepen K, Seabright GE, Lee WH, Aldon Y, Rantalainen K, Antanasijevic A, Copps J, Yasmeen A, Cupo A, Cruz Portillo VM, Poniman M, Bol N, van der Woude P, de Taeye SW, van den Kerkhof TLGM, Klasse PJ, Ozorowski G, van Gils MJ, Moore JP, Ward AB, Crispin M, Sanders RW. Derking R, et al. Among authors: lee wh. Cell Rep. 2021 Apr 6;35(1):108933. doi: 10.1016/j.celrep.2021.108933. Cell Rep. 2021. PMID: 33826885 Free PMC article.
Antibodies from Rabbits Immunized with HIV-1 Clade B SOSIP Trimers Can Neutralize Multiple Clade B Viruses by Destabilizing the Envelope Glycoprotein.
van Haaren MM, McCoy LE, Torres JL, Lee W, Cottrell CA, Copps JL, van der Woude P, Yasmeen A, de Taeye SW, Torrents de la Peña A, Moore JP, Burton DR, Klasse PJ, Ward AB, Sanders RW, van Gils MJ. van Haaren MM, et al. J Virol. 2021 Aug 10;95(17):e0009421. doi: 10.1128/JVI.00094-21. Epub 2021 Aug 10. J Virol. 2021. PMID: 34076487 Free PMC article.
Murine Monoclonal Antibodies against the Receptor Binding Domain of SARS-CoV-2 Neutralize Authentic Wild-Type SARS-CoV-2 as Well as B.1.1.7 and B.1.351 Viruses and Protect In Vivo in a Mouse Model in a Neutralization-Dependent Manner.
Amanat F, Strohmeier S, Lee WH, Bangaru S, Ward AB, Coughlan L, Krammer F. Amanat F, et al. Among authors: lee wh. mBio. 2021 Aug 31;12(4):e0100221. doi: 10.1128/mBio.01002-21. Epub 2021 Jul 27. mBio. 2021. PMID: 34311574 Free PMC article.
2,470 results