Bunney TD - Search Results

1

TREM2/PLCγ2 signalling in immune cells: function, structural insight, and potential therapeutic modulation.

Magno L, Bunney TD, Mead E, Svensson F, Bictash MN. Magno L, et al. Among authors: bunney td. Mol Neurodegener. 2021 Apr 6;16(1):22. doi: 10.1186/s13024-021-00436-5. Mol Neurodegener. 2021. PMID: 33823896 Free PMC article. Review.

2

Structural insights into formation of an active signaling complex between Rac and phospholipase C gamma 2.

Bunney TD, Opaleye O, Roe SM, Vatter P, Baxendale RW, Walliser C, Everett KL, Josephs MB, Christow C, Rodrigues-Lima F, Gierschik P, Pearl LH, Katan M. Bunney TD, et al. Mol Cell. 2009 Apr 24;34(2):223-33. doi: 10.1016/j.molcel.2009.02.023. Mol Cell. 2009. PMID: 19394299 Free article.

3

Structural and functional integration of the PLCγ interaction domains critical for regulatory mechanisms and signaling deregulation.

Bunney TD, Esposito D, Mas-Droux C, Lamber E, Baxendale RW, Martins M, Cole A, Svergun D, Driscoll PC, Katan M. Bunney TD, et al. Structure. 2012 Dec 5;20(12):2062-75. doi: 10.1016/j.str.2012.09.005. Epub 2012 Oct 11. Structure. 2012. PMID: 23063561 Free PMC article.

4

Dysfunction of phospholipase Cγ in immune disorders and cancer.

Koss H, Bunney TD, Behjati S, Katan M. Koss H, et al. Among authors: bunney td. Trends Biochem Sci. 2014 Dec;39(12):603-11. doi: 10.1016/j.tibs.2014.09.004. Epub 2014 Oct 30. Trends Biochem Sci. 2014. PMID: 25456276 Review.

5

Dynamic Allostery in PLCγ1 and Its Modulation by a Cancer Mutation Revealed by MD Simulation and NMR.

Koss H, Bunney TD, Esposito D, Martins M, Katan M, Driscoll PC. Koss H, et al. Among authors: bunney td. Biophys J. 2018 Jul 3;115(1):31-45. doi: 10.1016/j.bpj.2018.05.031. Biophys J. 2018. PMID: 29972810 Free PMC article.

6

Structural insights and activating mutations in diverse pathologies define mechanisms of deregulation for phospholipase C gamma enzymes.

Liu Y, Bunney TD, Khosa S, Macé K, Beckenbauer K, Askwith T, Maslen S, Stubbs C, de Oliveira TM, Sader K, Skehel M, Gavin AC, Phillips C, Katan M. Liu Y, et al. Among authors: bunney td. EBioMedicine. 2020 Jan;51:102607. doi: 10.1016/j.ebiom.2019.102607. Epub 2020 Jan 6. EBioMedicine. 2020. PMID: 31918402 Free PMC article.

7

Characterisation of molecular mechanisms for PLCγ2 disease-linked variants.

Bunney TD, Kampyli C, Gregory A, Katan M. Bunney TD, et al. Adv Biol Regul. 2024 Dec;94:101053. doi: 10.1016/j.jbior.2024.101053. Epub 2024 Sep 19. Adv Biol Regul. 2024. PMID: 39313402 Review.

8

Crystal structure of the human, FIC-domain containing protein HYPE and implications for its functions.

Bunney TD, Cole AR, Broncel M, Esposito D, Tate EW, Katan M. Bunney TD, et al. Structure. 2014 Dec 2;22(12):1831-1843. doi: 10.1016/j.str.2014.10.007. Structure. 2014. PMID: 25435325 Free PMC article.

9

Time-resolved FRET reports FGFR1 dimerization and formation of a complex with its effector PLCγ1.

Perdios L, Bunney TD, Warren SC, Dunsby C, French PMW, Tate EW, Katan M. Perdios L, et al. Among authors: bunney td. Adv Biol Regul. 2016 Jan;60:6-13. doi: 10.1016/j.jbior.2015.09.002. Epub 2015 Sep 26. Adv Biol Regul. 2016. PMID: 26482290 Free PMC article.

10

Targeting the Src Pathway Enhances the Efficacy of Selective FGFR Inhibitors in Urothelial Cancers with FGFR3 Alterations.

Lima NC, Atkinson E, Bunney TD, Katan M, Huang PH. Lima NC, et al. Among authors: bunney td. Int J Mol Sci. 2020 May 1;21(9):3214. doi: 10.3390/ijms21093214. Int J Mol Sci. 2020. PMID: 32370101 Free PMC article.

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