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FGF21 is required for the metabolic benefits of IKKε/TBK1 inhibition.
Reilly SM, Abu-Odeh M, Ameka M, DeLuca JH, Naber MC, Dadpey B, Ebadat N, Gomez AV, Peng X, Poirier B, Walk E, Potthoff MJ, Saltiel AR. Reilly SM, et al. Among authors: gomez av. J Clin Invest. 2021 May 17;131(10):e145546. doi: 10.1172/JCI145546. J Clin Invest. 2021. PMID: 33822771 Free PMC article.
Inhibition of IKKɛ and TBK1 Improves Glucose Control in a Subset of Patients with Type 2 Diabetes.
Oral EA, Reilly SM, Gomez AV, Meral R, Butz L, Ajluni N, Chenevert TL, Korytnaya E, Neidert AH, Hench R, Rus D, Horowitz JF, Poirier B, Zhao P, Lehmann K, Jain M, Yu R, Liddle C, Ahmadian M, Downes M, Evans RM, Saltiel AR. Oral EA, et al. Among authors: gomez av. Cell Metab. 2017 Jul 5;26(1):157-170.e7. doi: 10.1016/j.cmet.2017.06.006. Cell Metab. 2017. PMID: 28683283 Free PMC article. Clinical Trial.
Design, synthesis, and biological activity of substituted 2-amino-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid derivatives as inhibitors of the inflammatory kinases TBK1 and IKKε for the treatment of obesity.
Beyett TS, Gan X, Reilly SM, Gomez AV, Chang L, Tesmer JJG, Saltiel AR, Showalter HD. Beyett TS, et al. Among authors: gomez av. Bioorg Med Chem. 2018 Nov 1;26(20):5443-5461. doi: 10.1016/j.bmc.2018.09.020. Epub 2018 Sep 20. Bioorg Med Chem. 2018. PMID: 30270002 Free PMC article.
ERRγ Preserves Brown Fat Innate Thermogenic Activity.
Ahmadian M, Liu S, Reilly SM, Hah N, Fan W, Yoshihara E, Jha P, De Magalhaes Filho CD, Jacinto S, Gomez AV, Dai Y, Yu RT, Liddle C, Atkins AR, Auwerx J, Saltiel AR, Downes M, Evans RM. Ahmadian M, et al. Among authors: gomez av. Cell Rep. 2018 Mar 13;22(11):2849-2859. doi: 10.1016/j.celrep.2018.02.061. Cell Rep. 2018. PMID: 29539415 Free PMC article.
28 results