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A phase 2 trial of gemcitabine and docetaxel in patients with metastatic colorectal adenocarcinoma with methylated checkpoint with forkhead and ring finger domain promoter and/or microsatellite instability phenotype.
Baretti M, Karunasena E, Zahurak M, Walker R, Zhao Y, Pisanic TR 2nd, Wang TH, Greten TF, Duffy AG, Gootjes E, Meijer G, Verheul HMW, Ahuja N, Herman JG, Azad NS. Baretti M, et al. Among authors: meijer g. Clin Transl Sci. 2021 May;14(3):954-963. doi: 10.1111/cts.12960. Epub 2021 Apr 3. Clin Transl Sci. 2021. PMID: 33811727 Free PMC article. Clinical Trial.
Integrated analysis of chromosomal, microsatellite and epigenetic instability in colorectal cancer identifies specific associations between promoter methylation of pivotal tumour suppressor and DNA repair genes and specific chromosomal alterations.
Derks S, Postma C, Carvalho B, van den Bosch SM, Moerkerk PT, Herman JG, Weijenberg MP, de Bruïne AP, Meijer GA, van Engeland M. Derks S, et al. Among authors: meijer ga. Carcinogenesis. 2008 Feb;29(2):434-9. doi: 10.1093/carcin/bgm270. Epub 2007 Nov 28. Carcinogenesis. 2008. PMID: 18048385
Promoter CpG island hypermethylation- and H3K9me3 and H3K27me3-mediated epigenetic silencing targets the deleted in colon cancer (DCC) gene in colorectal carcinogenesis without affecting neighboring genes on chromosomal region 18q21.
Derks S, Bosch LJ, Niessen HE, Moerkerk PT, van den Bosch SM, Carvalho B, Mongera S, Voncken JW, Meijer GA, de Bruïne AP, Herman JG, van Engeland M. Derks S, et al. Among authors: meijer ga. Carcinogenesis. 2009 Jun;30(6):1041-8. doi: 10.1093/carcin/bgp073. Epub 2009 Mar 27. Carcinogenesis. 2009. PMID: 19329758
Methylation of TFPI2 in stool DNA: a potential novel biomarker for the detection of colorectal cancer.
Glöckner SC, Dhir M, Yi JM, McGarvey KE, Van Neste L, Louwagie J, Chan TA, Kleeberger W, de Bruïne AP, Smits KM, Khalid-de Bakker CA, Jonkers DM, Stockbrügger RW, Meijer GA, Oort FA, Iacobuzio-Donahue C, Bierau K, Herman JG, Baylin SB, Van Engeland M, Schuebel KE, Ahuja N. Glöckner SC, et al. Among authors: meijer ga. Cancer Res. 2009 Jun 1;69(11):4691-9. doi: 10.1158/0008-5472.CAN-08-0142. Epub 2009 May 12. Cancer Res. 2009. PMID: 19435926 Free PMC article.
GATA4 and GATA5 are potential tumor suppressors and biomarkers in colorectal cancer.
Hellebrekers DM, Lentjes MH, van den Bosch SM, Melotte V, Wouters KA, Daenen KL, Smits KM, Akiyama Y, Yuasa Y, Sanduleanu S, Khalid-de Bakker CA, Jonkers D, Weijenberg MP, Louwagie J, van Criekinge W, Carvalho B, Meijer GA, Baylin SB, Herman JG, de Bruïne AP, van Engeland M. Hellebrekers DM, et al. Among authors: meijer ga. Clin Cancer Res. 2009 Jun 15;15(12):3990-7. doi: 10.1158/1078-0432.CCR-09-0055. Epub 2009 Jun 9. Clin Cancer Res. 2009. PMID: 19509152
N-Myc downstream-regulated gene 4 (NDRG4): a candidate tumor suppressor gene and potential biomarker for colorectal cancer.
Melotte V, Lentjes MH, van den Bosch SM, Hellebrekers DM, de Hoon JP, Wouters KA, Daenen KL, Partouns-Hendriks IE, Stessels F, Louwagie J, Smits KM, Weijenberg MP, Sanduleanu S, Khalid-de Bakker CA, Oort FA, Meijer GA, Jonkers DM, Herman JG, de Bruïne AP, van Engeland M. Melotte V, et al. Among authors: meijer ga. J Natl Cancer Inst. 2009 Jul 1;101(13):916-27. doi: 10.1093/jnci/djp131. Epub 2009 Jun 17. J Natl Cancer Inst. 2009. PMID: 19535783
Subnuclear proteomics in colorectal cancer: identification of proteins enriched in the nuclear matrix fraction and regulation in adenoma to carcinoma progression.
Albrethsen J, Knol JC, Piersma SR, Pham TV, de Wit M, Mongera S, Carvalho B, Verheul HM, Fijneman RJ, Meijer GA, Jimenez CR. Albrethsen J, et al. Mol Cell Proteomics. 2010 May;9(5):988-1005. doi: 10.1074/mcp.M900546-MCP200. Epub 2010 Jan 20. Mol Cell Proteomics. 2010. PMID: 20089989 Free PMC article.
Colorectal cancer epigenetics: complex simplicity.
van Engeland M, Derks S, Smits KM, Meijer GA, Herman JG. van Engeland M, et al. Among authors: meijer ga. J Clin Oncol. 2011 Apr 1;29(10):1382-91. doi: 10.1200/JCO.2010.28.2319. Epub 2011 Jan 10. J Clin Oncol. 2011. PMID: 21220596 Review.
1,087 results