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Therapeutic inhibition of the miR-34 family attenuates pathological cardiac remodeling and improves heart function.
Bernardo BC, Gao XM, Winbanks CE, Boey EJ, Tham YK, Kiriazis H, Gregorevic P, Obad S, Kauppinen S, Du XJ, Lin RC, McMullen JR. Bernardo BC, et al. Among authors: winbanks ce. Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17615-20. doi: 10.1073/pnas.1206432109. Epub 2012 Oct 9. Proc Natl Acad Sci U S A. 2012. PMID: 23047694 Free PMC article.
Therapeutic silencing of miR-652 restores heart function and attenuates adverse remodeling in a setting of established pathological hypertrophy.
Bernardo BC, Nguyen SS, Winbanks CE, Gao XM, Boey EJ, Tham YK, Kiriazis H, Ooi JY, Porrello ER, Igoor S, Thomas CJ, Gregorevic P, Lin RC, Du XJ, McMullen JR. Bernardo BC, et al. Among authors: winbanks ce. FASEB J. 2014 Dec;28(12):5097-110. doi: 10.1096/fj.14-253856. Epub 2014 Aug 21. FASEB J. 2014. PMID: 25145628
The bone morphogenetic protein axis is a positive regulator of skeletal muscle mass.
Winbanks CE, Chen JL, Qian H, Liu Y, Bernardo BC, Beyer C, Watt KI, Thomson RE, Connor T, Turner BJ, McMullen JR, Larsson L, McGee SL, Harrison CA, Gregorevic P. Winbanks CE, et al. J Cell Biol. 2013 Oct 28;203(2):345-57. doi: 10.1083/jcb.201211134. Epub 2013 Oct 21. J Cell Biol. 2013. PMID: 24145169 Free PMC article.
Smad7 gene delivery prevents muscle wasting associated with cancer cachexia in mice.
Winbanks CE, Murphy KT, Bernardo BC, Qian H, Liu Y, Sepulveda PV, Beyer C, Hagg A, Thomson RE, Chen JL, Walton KL, Loveland KL, McMullen JR, Rodgers BD, Harrison CA, Lynch GS, Gregorevic P. Winbanks CE, et al. Sci Transl Med. 2016 Jul 20;8(348):348ra98. doi: 10.1126/scitranslmed.aac4976. Sci Transl Med. 2016. PMID: 27440729
22 results