Jain M - Search Results

1

The tumor suppressor kinase DAPK3 drives tumor-intrinsic immunity through the STING-IFN-β pathway.

Takahashi M, Lio CJ, Campeau A, Steger M, Ay F, Mann M, Gonzalez DJ, Jain M, Sharma S. Takahashi M, et al. Among authors: jain m. Nat Immunol. 2021 Apr;22(4):485-496. doi: 10.1038/s41590-021-00896-3. Epub 2021 Mar 25. Nat Immunol. 2021. PMID: 33767426 Free PMC article.

2

An siRNA screen for NFAT activation identifies septins as coordinators of store-operated Ca2+ entry.

Sharma S, Quintana A, Findlay GM, Mettlen M, Baust B, Jain M, Nilsson R, Rao A, Hogan PG. Sharma S, et al. Among authors: jain m. Nature. 2013 Jul 11;499(7457):238-42. doi: 10.1038/nature12229. Epub 2013 Jun 23. Nature. 2013. PMID: 23792561 Free PMC article.

3

Cellular sensing of extracellular purine nucleosides triggers an innate IFN-β response.

Dhanwani R, Takahashi M, Mathews IT, Lenzi C, Romanov A, Watrous JD, Pieters B, Hedrick CC, Benedict CA, Linden J, Nilsson R, Jain M, Sharma S. Dhanwani R, et al. Among authors: jain m. Sci Adv. 2020 Jul 22;6(30):eaba3688. doi: 10.1126/sciadv.aba3688. eCollection 2020 Jul. Sci Adv. 2020. PMID: 32743071 Free PMC article.

4

Functional Analysis of Immune Signature Genes in Th1* Memory Cells Links ISOC1 and Pyrimidine Metabolism to IFN-γ and IL-17 Production.

Kushnareva Y, Mathews IT, Andreyev AY, Altay G, Lindestam Arlehamn CS, Pandurangan V, Nilsson R, Jain M, Sette A, Peters B, Sharma S. Kushnareva Y, et al. Among authors: jain m. J Immunol. 2021 Mar 15;206(6):1181-1193. doi: 10.4049/jimmunol.2000672. Epub 2021 Feb 5. J Immunol. 2021. PMID: 33547171 Free PMC article.

5

Integration of metabolomics, genomics, and immune phenotypes reveals the causal roles of metabolites in disease.

Chu X, Jaeger M, Beumer J, Bakker OB, Aguirre-Gamboa R, Oosting M, Smeekens SP, Moorlag S, Mourits VP, Koeken VACM, de Bree C, Jansen T, Mathews IT, Dao K, Najhawan M, Watrous JD, Joosten I, Sharma S, Koenen HJPM, Withoff S, Jonkers IH, Netea-Maier RT, Xavier RJ, Franke L, Xu CJ, Joosten LAB, Sanna S, Jain M, Kumar V, Clevers H, Wijmenga C, Netea MG, Li Y. Chu X, et al. Among authors: jain m. Genome Biol. 2021 Jul 6;22(1):198. doi: 10.1186/s13059-021-02413-z. Genome Biol. 2021. PMID: 34229738 Free PMC article.

6

Genome-wide CRISPR/Cas9 screening in human iPS derived cardiomyocytes uncovers novel mediators of doxorubicin cardiotoxicity.

Sapp V, Aguirre A, Mainkar G, Ding J, Adler E, Liao R, Sharma S, Jain M. Sapp V, et al. Among authors: jain m. Sci Rep. 2021 Jul 6;11(1):13866. doi: 10.1038/s41598-021-92988-1. Sci Rep. 2021. PMID: 34230586 Free PMC article.

7

Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation.

Jain M, Nilsson R, Sharma S, Madhusudhan N, Kitami T, Souza AL, Kafri R, Kirschner MW, Clish CB, Mootha VK. Jain M, et al. Science. 2012 May 25;336(6084):1040-4. doi: 10.1126/science.1218595. Science. 2012. PMID: 22628656 Free PMC article.

8

Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer.

Nilsson R, Jain M, Madhusudhan N, Sheppard NG, Strittmatter L, Kampf C, Huang J, Asplund A, Mootha VK. Nilsson R, et al. Among authors: jain m. Nat Commun. 2014;5:3128. doi: 10.1038/ncomms4128. Nat Commun. 2014. PMID: 24451681 Free PMC article.

9

The glutamate/cystine xCT antiporter antagonizes glutamine metabolism and reduces nutrient flexibility.

Shin CS, Mishra P, Watrous JD, Carelli V, D'Aurelio M, Jain M, Chan DC. Shin CS, et al. Among authors: jain m. Nat Commun. 2017 Apr 21;8:15074. doi: 10.1038/ncomms15074. Nat Commun. 2017. PMID: 28429737 Free PMC article.

10

Directed Non-targeted Mass Spectrometry and Chemical Networking for Discovery of Eicosanoids and Related Oxylipins.

Watrous JD, Niiranen TJ, Lagerborg KA, Henglin M, Xu YJ, Rong J, Sharma S, Vasan RS, Larson MG, Armando A, Mora S, Quehenberger O, Dennis EA, Cheng S, Jain M. Watrous JD, et al. Among authors: jain m. Cell Chem Biol. 2019 Mar 21;26(3):433-442.e4. doi: 10.1016/j.chembiol.2018.11.015. Epub 2019 Jan 17. Cell Chem Biol. 2019. PMID: 30661990 Free PMC article.

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