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Rationally designed immunogens enable immune focusing to the SARS-CoV-2 receptor binding motif.
Hauser BM, Sangesland M, Denis KJS, Windsor IW, Feldman J, Lam EC, Kannegieter T, Balazs AB, Lingwood D, Schmidt AG. Hauser BM, et al. Among authors: lam ec. bioRxiv [Preprint]. 2021 Jul 9:2021.03.15.435440. doi: 10.1101/2021.03.15.435440. bioRxiv. 2021. Update in: Cell Rep. 2022 Mar 22;38(12):110561. doi: 10.1016/j.celrep.2022.110561 PMID: 33758851 Free PMC article. Updated. Preprint.
COVID-19 neutralizing antibodies predict disease severity and survival.
Garcia-Beltran WF, Lam EC, Astudillo MG, Yang D, Miller TE, Feldman J, Hauser BM, Caradonna TM, Clayton KL, Nitido AD, Murali MR, Alter G, Charles RC, Dighe A, Branda JA, Lennerz JK, Lingwood D, Schmidt AG, Iafrate AJ, Balazs AB. Garcia-Beltran WF, et al. Among authors: lam ec. medRxiv [Preprint]. 2020 Oct 20:2020.10.15.20213512. doi: 10.1101/2020.10.15.20213512. medRxiv. 2020. Update in: Cell. 2021 Jan 21;184(2):476-488.e11. doi: 10.1016/j.cell.2020.12.015 PMID: 33106822 Free PMC article. Updated. Preprint.
SARS-CoV-2 viral load is associated with increased disease severity and mortality.
Fajnzylber J, Regan J, Coxen K, Corry H, Wong C, Rosenthal A, Worrall D, Giguel F, Piechocka-Trocha A, Atyeo C, Fischinger S, Chan A, Flaherty KT, Hall K, Dougan M, Ryan ET, Gillespie E, Chishti R, Li Y, Jilg N, Hanidziar D, Baron RM, Baden L, Tsibris AM, Armstrong KA, Kuritzkes DR, Alter G, Walker BD, Yu X, Li JZ; Massachusetts Consortium for Pathogen Readiness. Fajnzylber J, et al. Nat Commun. 2020 Oct 30;11(1):5493. doi: 10.1038/s41467-020-19057-5. Nat Commun. 2020. PMID: 33127906 Free PMC article.
Quick COVID-19 Healers Sustain Anti-SARS-CoV-2 Antibody Production.
Chen Y, Zuiani A, Fischinger S, Mullur J, Atyeo C, Travers M, Lelis FJN, Pullen KM, Martin H, Tong P, Gautam A, Habibi S, Bensko J, Gakpo D, Feldman J, Hauser BM, Caradonna TM, Cai Y, Burke JS, Lin J, Lederer JA, Lam EC, Lavine CL, Seaman MS, Chen B, Schmidt AG, Balazs AB, Lauffenburger DA, Alter G, Wesemann DR. Chen Y, et al. Among authors: lam ec. Cell. 2020 Dec 10;183(6):1496-1507.e16. doi: 10.1016/j.cell.2020.10.051. Epub 2020 Nov 3. Cell. 2020. PMID: 33171099 Free PMC article.
COVID-19-neutralizing antibodies predict disease severity and survival.
Garcia-Beltran WF, Lam EC, Astudillo MG, Yang D, Miller TE, Feldman J, Hauser BM, Caradonna TM, Clayton KL, Nitido AD, Murali MR, Alter G, Charles RC, Dighe A, Branda JA, Lennerz JK, Lingwood D, Schmidt AG, Iafrate AJ, Balazs AB. Garcia-Beltran WF, et al. Among authors: lam ec. Cell. 2021 Jan 21;184(2):476-488.e11. doi: 10.1016/j.cell.2020.12.015. Epub 2020 Dec 15. Cell. 2021. PMID: 33412089 Free PMC article.
Naive human B cells engage the receptor binding domain of SARS-CoV-2, variants of concern, and related sarbecoviruses.
Feldman J, Bals J, Altomare CG, St Denis K, Lam EC, Hauser BM, Ronsard L, Sangesland M, Moreno TB, Okonkwo V, Hartojo N, Balazs AB, Bajic G, Lingwood D, Schmidt AG. Feldman J, et al. Among authors: lam ec. bioRxiv [Preprint]. 2021 Jul 9:2021.02.02.429458. doi: 10.1101/2021.02.02.429458. bioRxiv. 2021. Update in: Sci Immunol. 2021 Dec 10;6(66):eabl5842. doi: 10.1126/sciimmunol.abl5842 PMID: 33594359 Free PMC article. Updated. Preprint.
Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity.
Garcia-Beltran WF, Lam EC, St Denis K, Nitido AD, Garcia ZH, Hauser BM, Feldman J, Pavlovic MN, Gregory DJ, Poznansky MC, Sigal A, Schmidt AG, Iafrate AJ, Naranbhai V, Balazs AB. Garcia-Beltran WF, et al. Among authors: lam ec. medRxiv [Preprint]. 2021 Mar 12:2021.02.14.21251704. doi: 10.1101/2021.02.14.21251704. medRxiv. 2021. Update in: Cell. 2021 Apr 29;184(9):2372-2383.e9. doi: 10.1016/j.cell.2021.03.013 Update in: Cell. 2021 Apr 29;184(9):2523. doi: 10.1016/j.cell.2021.04.006 PMID: 33619506 Free PMC article. Updated. Preprint.
Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity.
Garcia-Beltran WF, Lam EC, St Denis K, Nitido AD, Garcia ZH, Hauser BM, Feldman J, Pavlovic MN, Gregory DJ, Poznansky MC, Sigal A, Schmidt AG, Iafrate AJ, Naranbhai V, Balazs AB. Garcia-Beltran WF, et al. Among authors: lam ec. Cell. 2021 Apr 29;184(9):2372-2383.e9. doi: 10.1016/j.cell.2021.03.013. Epub 2021 Mar 12. Cell. 2021. PMID: 33743213 Free PMC article.
87 results