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Rationally designed immunogens enable immune focusing to the SARS-CoV-2 receptor binding motif.
Hauser BM, Sangesland M, Denis KJS, Windsor IW, Feldman J, Lam EC, Kannegieter T, Balazs AB, Lingwood D, Schmidt AG. Hauser BM, et al. Among authors: denis kjs. bioRxiv [Preprint]. 2021 Jul 9:2021.03.15.435440. doi: 10.1101/2021.03.15.435440. bioRxiv. 2021. Update in: Cell Rep. 2022 Mar 22;38(12):110561. doi: 10.1016/j.celrep.2022.110561 PMID: 33758851 Free PMC article. Updated. Preprint.
T cell reactivity to the SARS-CoV-2 Omicron variant is preserved in most but not all prior infected and vaccinated individuals.
Naranbhai V, Nathan A, Kaseke C, Berrios C, Khatri A, Choi S, Getz MA, Tano-Menka R, Ofoman O, Gayton A, Senjobe F, Denis KJS, Lam EC, Garcia-Beltran WF, Balazs AB, Walker BD, Iafrate AJ, Gaiha GD. Naranbhai V, et al. Among authors: denis kjs. medRxiv [Preprint]. 2022 Jan 5:2022.01.04.21268586. doi: 10.1101/2022.01.04.21268586. medRxiv. 2022. Update in: Cell. 2022 Mar 17;185(6):1041-1051.e6. doi: 10.1016/j.cell.2022.01.029 PMID: 35018386 Free PMC article. Updated. Preprint.
Heterologous sarbecovirus receptor binding domains as scaffolds for SARS-CoV-2 receptor binding motif presentation.
Hauser BM, Sangesland M, Lam EC, Denis KJS, Sheehan ML, Vu ML, Cheng AH, Balazs AB, Lingwood D, Schmidt AG. Hauser BM, et al. Among authors: denis kjs. bioRxiv [Preprint]. 2023 Aug 22:2023.08.21.554179. doi: 10.1101/2023.08.21.554179. bioRxiv. 2023. Update in: ACS Infect Dis. 2024 Feb 9;10(2):553-561. doi: 10.1021/acsinfecdis.3c00483 PMID: 37662405 Free PMC article. Updated. Preprint.