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Biallelic mutations in IQCN, encoding a novel acroplaxome protein, lead to fertilization failure and male infertility with defects in the acrosome and shaping of the spermatid head in humans and mice.
Sha Y, Chen Y, Wang X, Meng R, Yang X, Li Y, Jin P, Li S, Chen J, Shao T, Xu D, Guo Y, Jiang Z, Li Y, Yu S, Li L, Wang F. Sha Y, et al. Among authors: li s. Life Med. 2022 Nov 4;2(2):lnac050. doi: 10.1093/lifemedi/lnac050. eCollection 2023 Apr. Life Med. 2022. PMID: 39872118 Free PMC article. No abstract available.
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