Lunn G - Search Results

1

Discovery of Sisunatovir (RV521), an Inhibitor of Respiratory Syncytial Virus Fusion.

Cockerill GS, Angell RM, Bedernjak A, Chuckowree I, Fraser I, Gascon-Simorte J, Gilman MSA, Good JAD, Harland R, Johnson SM, Ludes-Meyers JH, Littler E, Lumley J, Lunn G, Mathews N, McLellan JS, Paradowski M, Peeples ME, Scott C, Tait D, Taylor G, Thom M, Thomas E, Villalonga Barber C, Ward SE, Watterson D, Williams G, Young P, Powell K. Cockerill GS, et al. Among authors: lunn g. J Med Chem. 2021 Apr 8;64(7):3658-3676. doi: 10.1021/acs.jmedchem.0c01882. Epub 2021 Mar 17. J Med Chem. 2021. PMID: 33729773

2

Discovery of a Selective TRPM8 Antagonist with Clinical Efficacy in Cold-Related Pain.

Andrews MD, Af Forselles K, Beaumont K, Galan SR, Glossop PA, Grenie M, Jessiman A, Kenyon AS, Lunn G, Maw G, Owen RM, Pryde DC, Roberts D, Tran TD. Andrews MD, et al. Among authors: lunn g. ACS Med Chem Lett. 2015 Jan 30;6(4):419-24. doi: 10.1021/ml500479v. eCollection 2015 Apr 9. ACS Med Chem Lett. 2015. PMID: 25893043 Free PMC article.

3

Use of libraries to access new chemical space: applications to CRTH2.

Abid Masood M, Gardner M, Dack K, Winpenny D, Lunn G. Abid Masood M, et al. Among authors: lunn g. Bioorg Med Chem Lett. 2012 Jun 1;22(11):3682-7. doi: 10.1016/j.bmcl.2012.04.041. Epub 2012 Apr 20. Bioorg Med Chem Lett. 2012. PMID: 22560471

4

SAR and biological evaluation of 3-azabicyclo[3.1.0]hexane derivatives as μ opioid ligands.

Lunn G, Roberts LR, Content S, Critcher DJ, Douglas S, Fenwick AE, Gethin DM, Goodwin G, Greenway D, Greenwood S, Hall K, Thomas M, Thompson S, Williams D, Wood G, Wylie A. Lunn G, et al. Bioorg Med Chem Lett. 2012 Mar 15;22(6):2200-3. doi: 10.1016/j.bmcl.2012.01.099. Epub 2012 Feb 2. Bioorg Med Chem Lett. 2012. PMID: 22357342

5

Discovery and synthesis of a new class of opioid ligand having a 3-azabicyclo[3.1.0]hexane core. An example of a 'magic methyl' giving a 35-fold improvement in binding.

Lunn G, Banks BJ, Crook R, Feeder N, Pettman A, Sabnis Y. Lunn G, et al. Bioorg Med Chem Lett. 2011 Aug 1;21(15):4608-11. doi: 10.1016/j.bmcl.2011.05.132. Epub 2011 Jun 16. Bioorg Med Chem Lett. 2011. PMID: 21737265

6

Full efficacy with no CNS side-effects: unachievable panacea or reality? DMPK considerations in design of drugs with limited brain penetration.

Cole S, Bagal S, El-Kattan A, Fenner K, Hay T, Kempshall S, Lunn G, Varma M, Stupple P, Speed W. Cole S, et al. Among authors: lunn g. Xenobiotica. 2012 Jan;42(1):11-27. doi: 10.3109/00498254.2011.617847. Epub 2011 Oct 4. Xenobiotica. 2012. PMID: 21970687 Review.

7

Preliminary Evaluation of Stability Data for Dolutegravir-Containing Triple Active Formulations Intended for PEPFAR. Degradation of Tenofovir Disoproxil Fumarate and Tenofovir Alafenamide as the Limiting Factor.

Lunn G. Lunn G. J Pharm Sci. 2023 Jun;112(6):1733-1739. doi: 10.1016/j.xphs.2023.01.018. Epub 2023 Jan 26. J Pharm Sci. 2023. PMID: 36708963 Free PMC article.

8

Previous History of Knee Arthroscopy in Patients Undergoing Total Knee Arthroplasty: An Examination of the Effect of the Literature and American Academy of Orthopaedic Surgeons 2013 Arthroscopy Guidelines on Clinical Practice.

Kluczynski MA, Lunn G, Phillips MJ, Marzo JM. Kluczynski MA, et al. Among authors: lunn g. Arthrosc Sports Med Rehabil. 2021 Apr 5;3(3):e861-e866. doi: 10.1016/j.asmr.2021.02.006. eCollection 2021 Jun. Arthrosc Sports Med Rehabil. 2021. PMID: 34195655 Free PMC article.

9

Struvite formation and decomposition characteristics for ammonia and phosphorus recovery: A review of magnesium-ammonia-phosphate interactions.

Tansel B, Lunn G, Monje O. Tansel B, et al. Among authors: lunn g. Chemosphere. 2018 Mar;194:504-514. doi: 10.1016/j.chemosphere.2017.12.004. Epub 2017 Dec 5. Chemosphere. 2018. PMID: 29241124 Review.

10

Safe use of hazardous chemicals.

Lunn G, Lawler G. Lunn G, et al. Curr Protoc Microbiol. 2011 Nov;Chapter 1:Unit1A.3. doi: 10.1002/9780471729259.mc01a03s23. Curr Protoc Microbiol. 2011. PMID: 22045582

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