Frimurer TM - Search Results

1

Selective release of gastrointestinal hormones induced by an orally active GPR39 agonist.

Grunddal KV, Diep TA, Petersen N, Tough IR, Skov LJ, Liu L, Buijink JA, Mende F, Jin C, Jepsen SL, Sørensen LME, Achiam MP, Strandby RB, Bach A, Hartmann B, Frimurer TM, Hjorth SA, Bouvier M, Cox H, Holst B. Grunddal KV, et al. Among authors: frimurer tm. Mol Metab. 2021 Jul;49:101207. doi: 10.1016/j.molmet.2021.101207. Epub 2021 Mar 9. Mol Metab. 2021. PMID: 33711555 Free PMC article.

2

Molecular mechanism of 7TM receptor activation--a global toggle switch model.

Schwartz TW, Frimurer TM, Holst B, Rosenkilde MM, Elling CE. Schwartz TW, et al. Among authors: frimurer tm. Annu Rev Pharmacol Toxicol. 2006;46:481-519. doi: 10.1146/annurev.pharmtox.46.120604.141218. Annu Rev Pharmacol Toxicol. 2006. PMID: 16402913 Review.

3

Metal ion site engineering indicates a global toggle switch model for seven-transmembrane receptor activation.

Elling CE, Frimurer TM, Gerlach LO, Jorgensen R, Holst B, Schwartz TW. Elling CE, et al. Among authors: frimurer tm. J Biol Chem. 2006 Jun 23;281(25):17337-17346. doi: 10.1074/jbc.M512510200. Epub 2006 Mar 27. J Biol Chem. 2006. PMID: 16567806 Free article.

4

Ghrelin receptor inverse agonists: identification of an active peptide core and its interaction epitopes on the receptor.

Holst B, Lang M, Brandt E, Bach A, Howard A, Frimurer TM, Beck-Sickinger A, Schwartz TW. Holst B, et al. Among authors: frimurer tm. Mol Pharmacol. 2006 Sep;70(3):936-46. doi: 10.1124/mol.106.024422. Epub 2006 Jun 23. Mol Pharmacol. 2006. PMID: 16798937

5

Identification of an efficacy switch region in the ghrelin receptor responsible for interchange between agonism and inverse agonism.

Holst B, Mokrosinski J, Lang M, Brandt E, Nygaard R, Frimurer TM, Beck-Sickinger AG, Schwartz TW. Holst B, et al. Among authors: frimurer tm. J Biol Chem. 2007 May 25;282(21):15799-811. doi: 10.1074/jbc.M609796200. Epub 2007 Mar 19. J Biol Chem. 2007. PMID: 17371869 Free article.

6

Overlapping binding site for the endogenous agonist, small-molecule agonists, and ago-allosteric modulators on the ghrelin receptor.

Holst B, Frimurer TM, Mokrosinski J, Halkjaer T, Cullberg KB, Underwood CR, Schwartz TW. Holst B, et al. Among authors: frimurer tm. Mol Pharmacol. 2009 Jan;75(1):44-59. doi: 10.1124/mol.108.049189. Epub 2008 Oct 15. Mol Pharmacol. 2009. PMID: 18923064

7

Ligand binding and micro-switches in 7TM receptor structures.

Nygaard R, Frimurer TM, Holst B, Rosenkilde MM, Schwartz TW. Nygaard R, et al. Among authors: frimurer tm. Trends Pharmacol Sci. 2009 May;30(5):249-59. doi: 10.1016/j.tips.2009.02.006. Epub 2009 Apr 16. Trends Pharmacol Sci. 2009. PMID: 19375807 Review.

8

A conserved aromatic lock for the tryptophan rotameric switch in TM-VI of seven-transmembrane receptors.

Holst B, Nygaard R, Valentin-Hansen L, Bach A, Engelstoft MS, Petersen PS, Frimurer TM, Schwartz TW. Holst B, et al. Among authors: frimurer tm. J Biol Chem. 2010 Feb 5;285(6):3973-3985. doi: 10.1074/jbc.M109.064725. Epub 2009 Nov 17. J Biol Chem. 2010. PMID: 19920139 Free PMC article.

9

Unique interaction pattern for a functionally biased ghrelin receptor agonist.

Sivertsen B, Lang M, Frimurer TM, Holliday ND, Bach A, Els S, Engelstoft MS, Petersen PS, Madsen AN, Schwartz TW, Beck-Sickinger AG, Holst B. Sivertsen B, et al. Among authors: frimurer tm. J Biol Chem. 2011 Jun 10;286(23):20845-60. doi: 10.1074/jbc.M110.173237. Epub 2011 Mar 14. J Biol Chem. 2011. PMID: 21402696 Free PMC article.

10

Modulation of constitutive activity and signaling bias of the ghrelin receptor by conformational constraint in the second extracellular loop.

Mokrosiński J, Frimurer TM, Sivertsen B, Schwartz TW, Holst B. Mokrosiński J, et al. Among authors: frimurer tm. J Biol Chem. 2012 Sep 28;287(40):33488-502. doi: 10.1074/jbc.M112.383240. Epub 2012 Jul 30. J Biol Chem. 2012. PMID: 22846991 Free PMC article.

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