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HDAC6 inhibition restores TDP-43 pathology and axonal transport defects in human motor neurons with TARDBP mutations.
Fazal R, Boeynaems S, Swijsen A, De Decker M, Fumagalli L, Moisse M, Vanneste J, Guo W, Boon R, Vercruysse T, Eggermont K, Swinnen B, Beckers J, Pakravan D, Vandoorne T, Vanden Berghe P, Verfaillie C, Van Den Bosch L, Van Damme P. Fazal R, et al. Among authors: beckers j. EMBO J. 2021 Apr 1;40(7):e106177. doi: 10.15252/embj.2020106177. Epub 2021 Mar 10. EMBO J. 2021. PMID: 33694180 Free PMC article.
C9orf72-derived arginine-containing dipeptide repeats associate with axonal transport machinery and impede microtubule-based motility.
Fumagalli L, Young FL, Boeynaems S, De Decker M, Mehta AR, Swijsen A, Fazal R, Guo W, Moisse M, Beckers J, Dedeene L, Selvaraj BT, Vandoorne T, Madan V, van Blitterswijk M, Raitcheva D, McCampbell A, Poesen K, Gitler AD, Koch P, Vanden Berghe P, Thal DR, Verfaillie C, Chandran S, Van Den Bosch L, Bullock SL, Van Damme P. Fumagalli L, et al. Among authors: beckers j. Sci Adv. 2021 Apr 9;7(15):eabg3013. doi: 10.1126/sciadv.abg3013. Print 2021 Apr. Sci Adv. 2021. PMID: 33837088 Free PMC article.
Human motor units in microfluidic devices are impaired by FUS mutations and improved by HDAC6 inhibition.
Stoklund Dittlau K, Krasnow EN, Fumagalli L, Vandoorne T, Baatsen P, Kerstens A, Giacomazzi G, Pavie B, Rossaert E, Beckers J, Sampaolesi M, Van Damme P, Van Den Bosch L. Stoklund Dittlau K, et al. Among authors: beckers j. Stem Cell Reports. 2021 Sep 14;16(9):2213-2227. doi: 10.1016/j.stemcr.2021.03.029. Epub 2021 Apr 22. Stem Cell Reports. 2021. PMID: 33891869 Free PMC article.
HNRNPK alleviates RNA toxicity by counteracting DNA damage in C9orf72 ALS.
Braems E, Bercier V, Van Schoor E, Heeren K, Beckers J, Fumagalli L, Dedeene L, Moisse M, Geudens I, Hersmus N, Mehta AR, Selvaraj BT, Chandran S, Ho R, Thal DR, Van Damme P, Swinnen B, Van Den Bosch L. Braems E, et al. Among authors: beckers j. Acta Neuropathol. 2022 Sep;144(3):465-488. doi: 10.1007/s00401-022-02471-y. Epub 2022 Jul 27. Acta Neuropathol. 2022. PMID: 35895140 Free PMC article.
A pathogenic mutation in the ALS/FTD gene VCP induces mitochondrial hypermetabolism by modulating the permeability transition pore.
Vanderhaeghe S, Prerad J, Tharkeshwar AK, Goethals E, Vints K, Beckers J, Scheveneels W, Debroux E, Princen K, Van Damme P, Fivaz M, Griffioen G, Van Den Bosch L. Vanderhaeghe S, et al. Among authors: beckers j. Acta Neuropathol Commun. 2024 Oct 10;12(1):161. doi: 10.1186/s40478-024-01866-0. Acta Neuropathol Commun. 2024. PMID: 39390590 Free PMC article.
587 results