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Detection of a recurrent DNAJB1-PRKACA chimeric transcript in fibrolamellar hepatocellular carcinoma.
Honeyman JN, Simon EP, Robine N, Chiaroni-Clarke R, Darcy DG, Lim II, Gleason CE, Murphy JM, Rosenberg BR, Teegan L, Takacs CN, Botero S, Belote R, Germer S, Emde AK, Vacic V, Bhanot U, LaQuaglia MP, Simon SM. Honeyman JN, et al. Among authors: simon sm, simon ep. Science. 2014 Feb 28;343(6174):1010-4. doi: 10.1126/science.1249484. Science. 2014. PMID: 24578576 Free PMC article.
Structural analyses of the PKA RIIβ holoenzyme containing the oncogenic DnaJB1-PKAc fusion protein reveal protomer asymmetry and fusion-induced allosteric perturbations in fibrolamellar hepatocellular carcinoma.
Lu TW, Aoto PC, Weng JH, Nielsen C, Cash JN, Hall J, Zhang P, Simon SM, Cianfrocco MA, Taylor SS. Lu TW, et al. Among authors: simon sm. PLoS Biol. 2020 Dec 28;18(12):e3001018. doi: 10.1371/journal.pbio.3001018. eCollection 2020 Dec. PLoS Biol. 2020. PMID: 33370777 Free PMC article.
Author Correction: Defective internal allosteric network imparts dysfunctional ATP/substrate-binding cooperativity in oncogenic chimera of protein kinase A.
Olivieri C, Walker C, Karamafrooz A, Wang Y, Manu VS, Porcelli F, Blumenthal DK, Thomas DD, Bernlohr DA, Simon SM, Taylor SS, Veglia G. Olivieri C, et al. Among authors: simon sm. Commun Biol. 2021 Apr 6;4(1):446. doi: 10.1038/s42003-021-02006-3. Commun Biol. 2021. PMID: 33824409 Free PMC article. No abstract available.
DNAJB1-PRKACA fusion kinase interacts with β-catenin and the liver regenerative response to drive fibrolamellar hepatocellular carcinoma.
Kastenhuber ER, Lalazar G, Houlihan SL, Tschaharganeh DF, Baslan T, Chen CC, Requena D, Tian S, Bosbach B, Wilkinson JE, Simon SM, Lowe SW. Kastenhuber ER, et al. Among authors: simon sm. Proc Natl Acad Sci U S A. 2017 Dec 12;114(50):13076-13084. doi: 10.1073/pnas.1716483114. Epub 2017 Nov 21. Proc Natl Acad Sci U S A. 2017. PMID: 29162699 Free PMC article.
167 results