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Endogenous modification of the chemoattractant CXCL5 alters receptor usage and enhances its activity toward neutrophils and monocytes.
Metzemaekers M, Mortier A, Vacchini A, Boff D, Yu K, Janssens R, Farina FM, Milanesi S, Berghmans N, Pörtner N, Van Damme J, Allegretti M, Teixeira MM, Locati M, Borroni EM, Amaral FA, Proost P. Metzemaekers M, et al. Among authors: janssens r. Sci Signal. 2021 Mar 9;14(673):eaax3053. doi: 10.1126/scisignal.aax3053. Sci Signal. 2021. PMID: 33688078
The Positively Charged COOH-terminal Glycosaminoglycan-binding CXCL9(74-103) Peptide Inhibits CXCL8-induced Neutrophil Extravasation and Monosodium Urate Crystal-induced Gout in Mice.
Vanheule V, Janssens R, Boff D, Kitic N, Berghmans N, Ronsse I, Kungl AJ, Amaral FA, Teixeira MM, Van Damme J, Proost P, Mortier A. Vanheule V, et al. Among authors: janssens r. J Biol Chem. 2015 Aug 28;290(35):21292-304. doi: 10.1074/jbc.M115.649855. Epub 2015 Jul 16. J Biol Chem. 2015. PMID: 26183778 Free PMC article.
Truncation of CXCL12 by CD26 reduces its CXC chemokine receptor 4- and atypical chemokine receptor 3-dependent activity on endothelial cells and lymphocytes.
Janssens R, Mortier A, Boff D, Ruytinx P, Gouwy M, Vantilt B, Larsen O, Daugvilaite V, Rosenkilde MM, Parmentier M, Noppen S, Liekens S, Van Damme J, Struyf S, Teixeira MM, Amaral FA, Proost P. Janssens R, et al. Biochem Pharmacol. 2017 May 15;132:92-101. doi: 10.1016/j.bcp.2017.03.009. Epub 2017 Mar 18. Biochem Pharmacol. 2017. PMID: 28322746
Glycosaminoglycans Regulate CXCR3 Ligands at Distinct Levels: Protection against Processing by Dipeptidyl Peptidase IV/CD26 and Interference with Receptor Signaling.
Metzemaekers M, Mortier A, Janssens R, Boff D, Vanbrabant L, Lamoen N, Van Damme J, Teixeira MM, De Meester I, Amaral FA, Proost P. Metzemaekers M, et al. Among authors: janssens r. Int J Mol Sci. 2017 Jul 13;18(7):1513. doi: 10.3390/ijms18071513. Int J Mol Sci. 2017. PMID: 28703769 Free PMC article.
Peroxynitrite Exposure of CXCL12 Impairs Monocyte, Lymphocyte and Endothelial Cell Chemotaxis, Lymphocyte Extravasation in vivo and Anti-HIV-1 Activity.
Janssens R, Boff D, Ruytinx P, Mortier A, Vanheule V, Larsen O, Daugvilaite V, Rosenkilde MM, Noppen S, Liekens S, Schols D, De Meester I, Opdenakker G, Struyf S, Teixeira MM, Amaral FA, Proost P. Janssens R, et al. Front Immunol. 2018 Aug 28;9:1933. doi: 10.3389/fimmu.2018.01933. eCollection 2018. Front Immunol. 2018. PMID: 30233568 Free PMC article.
CXCL9-Derived Peptides Differentially Inhibit Neutrophil Migration In Vivo through Interference with Glycosaminoglycan Interactions.
Vanheule V, Boff D, Mortier A, Janssens R, Petri B, Kolaczkowska E, Kubes P, Berghmans N, Struyf S, Kungl AJ, Teixeira MM, Amaral FA, Proost P. Vanheule V, et al. Among authors: janssens r. Front Immunol. 2017 May 10;8:530. doi: 10.3389/fimmu.2017.00530. eCollection 2017. Front Immunol. 2017. PMID: 28539925 Free PMC article.
The unique structural and functional features of CXCL12.
Janssens R, Struyf S, Proost P. Janssens R, et al. Cell Mol Immunol. 2018 Apr;15(4):299-311. doi: 10.1038/cmi.2017.107. Epub 2017 Oct 30. Cell Mol Immunol. 2018. PMID: 29082918 Free PMC article. Review.
310 results