Chen SRW - Search Results

1

Novel RyR2 Mutation (G3118R) Is Associated With Autosomal Recessive Ventricular Fibrillation and Sudden Death: Clinical, Functional, and Computational Analysis.

Shauer A, Shor O, Wei J, Elitzur Y, Kucherenko N, Wang R, Chen SRW, Einav Y, Luria D. Shauer A, et al. Among authors: chen srw. J Am Heart Assoc. 2021 Mar 16;10(6):e017128. doi: 10.1161/JAHA.120.017128. Epub 2021 Mar 9. J Am Heart Assoc. 2021. PMID: 33686871 Free PMC article.

2

Enhanced basal activity of a cardiac Ca2+ release channel (ryanodine receptor) mutant associated with ventricular tachycardia and sudden death.

Jiang D, Xiao B, Zhang L, Chen SR. Jiang D, et al. Circ Res. 2002 Aug 9;91(3):218-25. doi: 10.1161/01.res.0000028455.36940.5e. Circ Res. 2002. PMID: 12169647

3

Isoform-dependent formation of heteromeric Ca2+ release channels (ryanodine receptors).

Xiao B, Masumiya H, Jiang D, Wang R, Sei Y, Zhang L, Murayama T, Ogawa Y, Lai FA, Wagenknecht T, Chen SR. Xiao B, et al. J Biol Chem. 2002 Nov 1;277(44):41778-85. doi: 10.1074/jbc.M208210200. Epub 2002 Sep 3. J Biol Chem. 2002. PMID: 12213830 Free article.

4

Localization of the 12.6-kDa FK506-binding protein (FKBP12.6) binding site to the NH2-terminal domain of the cardiac Ca2+ release channel (ryanodine receptor).

Masumiya H, Wang R, Zhang J, Xiao B, Chen SR. Masumiya H, et al. J Biol Chem. 2003 Feb 7;278(6):3786-92. doi: 10.1074/jbc.M210962200. Epub 2002 Nov 22. J Biol Chem. 2003. PMID: 12446682 Free article.

5

Three-dimensional localization of divergent region 3 of the ryanodine receptor to the clamp-shaped structures adjacent to the FKBP binding sites.

Zhang J, Liu Z, Masumiya H, Wang R, Jiang D, Li F, Wagenknecht T, Chen SR. Zhang J, et al. J Biol Chem. 2003 Apr 18;278(16):14211-8. doi: 10.1074/jbc.M213164200. Epub 2003 Feb 7. J Biol Chem. 2003. PMID: 12576471 Free article.

6

Residue Gln4863 within a predicted transmembrane sequence of the Ca2+ release channel (ryanodine receptor) is critical for ryanodine interaction.

Wang R, Zhang L, Bolstad J, Diao N, Brown C, Ruest L, Welch W, Williams AJ, Chen SR. Wang R, et al. J Biol Chem. 2003 Dec 19;278(51):51557-65. doi: 10.1074/jbc.M306788200. Epub 2003 Oct 13. J Biol Chem. 2003. PMID: 14557272 Free article.

7

The predicted TM10 transmembrane sequence of the cardiac Ca2+ release channel (ryanodine receptor) is crucial for channel activation and gating.

Wang R, Bolstad J, Kong H, Zhang L, Brown C, Chen SR. Wang R, et al. J Biol Chem. 2004 Jan 30;279(5):3635-42. doi: 10.1074/jbc.M311367200. Epub 2003 Oct 30. J Biol Chem. 2004. PMID: 14593104 Free article.

8

RyR2 mutations linked to ventricular tachycardia and sudden death reduce the threshold for store-overload-induced Ca2+ release (SOICR).

Jiang D, Xiao B, Yang D, Wang R, Choi P, Zhang L, Cheng H, Chen SR. Jiang D, et al. Proc Natl Acad Sci U S A. 2004 Aug 31;101(35):13062-7. doi: 10.1073/pnas.0402388101. Epub 2004 Aug 20. Proc Natl Acad Sci U S A. 2004. PMID: 15322274 Free PMC article.

9

The Gln4863Ala mutation within a putative, pore-lining trans-membrane helix of the cardiac ryanodine receptor channel alters both the kinetics of ryanoid interaction and the subsequent fractional conductance.

Ranatunga KM, Moreno-King TM, Tanna B, Wang R, Chen SR, Ruest L, Welch W, Williams AJ. Ranatunga KM, et al. Mol Pharmacol. 2005 Sep;68(3):840-6. doi: 10.1124/mol.105.012807. Epub 2005 Jun 14. Mol Pharmacol. 2005. PMID: 15955866

10

Localization of a disease-associated mutation site in the three-dimensional structure of the cardiac muscle ryanodine receptor.

Liu Z, Wang R, Zhang J, Chen SR, Wagenknecht T. Liu Z, et al. J Biol Chem. 2005 Nov 11;280(45):37941-7. doi: 10.1074/jbc.M505714200. Epub 2005 Sep 11. J Biol Chem. 2005. PMID: 16157601 Free PMC article.

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