Takai T - Search Results

1

Discovery of a Potent and Orally Bioavailable Melatonin Receptor Agonist.

Hoashi Y, Takai T, Kosugi Y, Nakashima M, Nakayama M, Hirai K, Uchikawa O, Koike T. Hoashi Y, et al. Among authors: takai t. J Med Chem. 2021 Mar 25;64(6):3059-3074. doi: 10.1021/acs.jmedchem.0c01836. Epub 2021 Mar 7. J Med Chem. 2021. PMID: 33682410

2

1,6-Dihydro-2H-indeno[5,4-b]furan derivatives: design, synthesis, and pharmacological characterization of a novel class of highly potent MT₂-selective agonists.

Koike T, Hoashi Y, Takai T, Nakayama M, Yukuhiro N, Ishikawa T, Hirai K, Uchikawa O. Koike T, et al. Among authors: takai t. J Med Chem. 2011 May 12;54(9):3436-44. doi: 10.1021/jm200221q. Epub 2011 Apr 7. J Med Chem. 2011. PMID: 21473625

3

Synthesis of a novel series of tricyclic dihydrofuran derivatives: discovery of 8,9-dihydrofuro[3,2-c]pyrazolo[1,5-a]pyridines as melatonin receptor (MT1/MT2) ligands.

Koike T, Takai T, Hoashi Y, Nakayama M, Kosugi Y, Nakashima M, Yoshikubo S, Hirai K, Uchikawa O. Koike T, et al. Among authors: takai t. J Med Chem. 2011 Jun 23;54(12):4207-18. doi: 10.1021/jm200385u. Epub 2011 May 24. J Med Chem. 2011. PMID: 21568291

4

Design and synthesis of piperazine derivatives as a novel class of γ-secretase modulators that selectively lower Aβ₄₂ production.

Takai T, Koike T, Honda E, Kajita Y, Nakamura M, Morimoto S, Hoashi Y, Kamata M, Watanabe T, Igari T, Terauchi J. Takai T, et al. Bioorg Med Chem. 2015 May 1;23(9):1923-34. doi: 10.1016/j.bmc.2015.03.055. Epub 2015 Mar 28. Bioorg Med Chem. 2015. PMID: 25842363

5

Discovery of a Novel Series of N-Phenylindoline-5-sulfonamide Derivatives as Potent, Selective, and Orally Bioavailable Acyl CoA:Monoacylglycerol Acyltransferase-2 Inhibitors.

Sato K, Takahagi H, Yoshikawa T, Morimoto S, Takai T, Hidaka K, Kamaura M, Kubo O, Adachi R, Ishii T, Maki T, Mochida T, Takekawa S, Nakakariya M, Amano N, Kitazaki T. Sato K, et al. Among authors: takai t. J Med Chem. 2015 May 14;58(9):3892-909. doi: 10.1021/acs.jmedchem.5b00178. Epub 2015 Apr 30. J Med Chem. 2015. PMID: 25897973

6

Discovery of novel 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine derivatives as γ-secretase modulators.

Takai T, Hoashi Y, Tomata Y, Morimoto S, Nakamura M, Watanabe T, Igari T, Koike T. Takai T, et al. Bioorg Med Chem Lett. 2015 Oct 1;25(19):4245-9. doi: 10.1016/j.bmcl.2015.07.101. Epub 2015 Aug 7. Bioorg Med Chem Lett. 2015. PMID: 26298496

7

Discovery and optimization of 1,7-disubstituted-2,2-dimethyl-2,3-dihydroquinazolin-4(1H)-ones as potent and selective PKCθ inhibitors.

Katoh T, Takai T, Yukawa T, Tsukamoto T, Watanabe E, Mototani H, Arita T, Hayashi H, Nakagawa H, Klein MG, Zou H, Sang BC, Snell G, Nakada Y. Katoh T, et al. Among authors: takai t. Bioorg Med Chem. 2016 Jun 1;24(11):2466-2475. doi: 10.1016/j.bmc.2016.04.008. Epub 2016 Apr 4. Bioorg Med Chem. 2016. PMID: 27117263

8

Discovery of novel 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine derivatives as γ-secretase modulators (Part 2).

Takai T, Koike T, Nakamura M, Kajita Y, Yamashita T, Taya N, Tsukamoto T, Watanabe T, Murakami K, Igari T, Kamata M. Takai T, et al. Bioorg Med Chem. 2016 Jul 15;24(14):3192-206. doi: 10.1016/j.bmc.2016.05.040. Epub 2016 May 20. Bioorg Med Chem. 2016. PMID: 27255179

9

Practical application of 3-substituted-2,6-difluoropyridines in drug discovery: Facile synthesis of novel protein kinase C theta inhibitors.

Katoh T, Tomata Y, Setoh M, Sasaki S, Takai T, Yoshitomi Y, Yukawa T, Nakagawa H, Fukumoto S, Tsukamoto T, Nakada Y. Katoh T, et al. Among authors: takai t. Bioorg Med Chem Lett. 2017 Jun 1;27(11):2497-2501. doi: 10.1016/j.bmcl.2017.03.099. Epub 2017 Apr 2. Bioorg Med Chem Lett. 2017. PMID: 28400232

10

Discovery of a novel B-cell lymphoma 6 (BCL6)-corepressor interaction inhibitor by utilizing structure-based drug design.

Yasui T, Yamamoto T, Sakai N, Asano K, Takai T, Yoshitomi Y, Davis M, Takagi T, Sakamoto K, Sogabe S, Kamada Y, Lane W, Snell G, Iwata M, Goto M, Inooka H, Sakamoto JI, Nakada Y, Imaeda Y. Yasui T, et al. Among authors: takai t. Bioorg Med Chem. 2017 Sep 1;25(17):4876-4886. doi: 10.1016/j.bmc.2017.07.037. Epub 2017 Jul 20. Bioorg Med Chem. 2017. PMID: 28760529

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