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Mitochondrial arginase-2 is essential for IL-10 metabolic reprogramming of inflammatory macrophages.
Dowling JK, Afzal R, Gearing LJ, Cervantes-Silva MP, Annett S, Davis GM, De Santi C, Assmann N, Dettmer K, Gough DJ, Bantug GR, Hamid FI, Nally FK, Duffy CP, Gorman AL, Liddicoat AM, Lavelle EC, Hess C, Oefner PJ, Finlay DK, Davey GP, Robson T, Curtis AM, Hertzog PJ, Williams BRG, McCoy CE. Dowling JK, et al. Among authors: lavelle ec. Nat Commun. 2021 Mar 5;12(1):1460. doi: 10.1038/s41467-021-21617-2. Nat Commun. 2021. PMID: 33674584 Free PMC article.
Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes.
Masters SL, Dunne A, Subramanian SL, Hull RL, Tannahill GM, Sharp FA, Becker C, Franchi L, Yoshihara E, Chen Z, Mullooly N, Mielke LA, Harris J, Coll RC, Mills KH, Mok KH, Newsholme P, Nuñez G, Yodoi J, Kahn SE, Lavelle EC, O'Neill LA. Masters SL, et al. Among authors: lavelle ec. Nat Immunol. 2010 Oct;11(10):897-904. doi: 10.1038/ni.1935. Epub 2010 Sep 12. Nat Immunol. 2010. PMID: 20835230 Free PMC article.
The Vaccine Adjuvant Chitosan Promotes Cellular Immunity via DNA Sensor cGAS-STING-Dependent Induction of Type I Interferons.
Carroll EC, Jin L, Mori A, Muñoz-Wolf N, Oleszycka E, Moran HBT, Mansouri S, McEntee CP, Lambe E, Agger EM, Andersen P, Cunningham C, Hertzog P, Fitzgerald KA, Bowie AG, Lavelle EC. Carroll EC, et al. Among authors: lavelle ec. Immunity. 2016 Mar 15;44(3):597-608. doi: 10.1016/j.immuni.2016.02.004. Epub 2016 Mar 2. Immunity. 2016. PMID: 26944200 Free PMC article.
Alum Activates the Bovine NLRP3 Inflammasome.
Harte C, Gorman AL, McCluskey S, Carty M, Bowie AG, Scott CJ, Meade KG, Lavelle EC. Harte C, et al. Among authors: lavelle ec. Front Immunol. 2017 Nov 9;8:1494. doi: 10.3389/fimmu.2017.01494. eCollection 2017. Front Immunol. 2017. PMID: 29209310 Free PMC article.
Modulation of innate immunity by cyclosporine A.
Liddicoat AM, Lavelle EC. Liddicoat AM, et al. Among authors: lavelle ec. Biochem Pharmacol. 2019 May;163:472-480. doi: 10.1016/j.bcp.2019.03.022. Epub 2019 Mar 15. Biochem Pharmacol. 2019. PMID: 30880061 Review.
Caspase-11 promotes allergic airway inflammation.
Zasłona Z, Flis E, Wilk MM, Carroll RG, Palsson-McDermott EM, Hughes MM, Diskin C, Banahan K, Ryan DG, Hooftman A, Misiak A, Kearney J, Lochnit G, Bertrams W, Greulich T, Schmeck B, McElvaney OJ, Mills KHG, Lavelle EC, Wygrecka M, Creagh EM, O'Neill LAJ. Zasłona Z, et al. Among authors: lavelle ec. Nat Commun. 2020 Feb 26;11(1):1055. doi: 10.1038/s41467-020-14945-2. Nat Commun. 2020. PMID: 32103022 Free PMC article.
137 results