Clark RE - Search Results

1

Discovery of a Novel CIP2A Variant (NOCIVA) with Clinical Relevance in Predicting TKI Resistance in Myeloid Leukemias.

Mäkelä E, Pavic K, Varila T, Salmenniemi U, Löyttyniemi E, Nagelli SG, Ammunét T, Kähäri VM, Clark RE, Elo LL, Bachanaboyina VK, Lucas CM, Itälä-Remes M, Westermarck J. Mäkelä E, et al. Among authors: clark re. Clin Cancer Res. 2021 May 15;27(10):2848-2860. doi: 10.1158/1078-0432.CCR-20-3679. Epub 2021 Mar 5. Clin Cancer Res. 2021. PMID: 33674272

2

The role of serial BCR-ABL transcript monitoring in predicting the emergence of BCR-ABL kinase mutations in imatinib-treated patients with chronic myeloid leukemia.

Wang L, Knight K, Lucas C, Clark RE. Wang L, et al. Among authors: clark re. Haematologica. 2006 Feb;91(2):235-9. Haematologica. 2006. PMID: 16461309

3

Cancerous inhibitor of PP2A (CIP2A) at diagnosis of chronic myeloid leukemia is a critical determinant of disease progression.

Lucas CM, Harris RJ, Giannoudis A, Copland M, Slupsky JR, Clark RE. Lucas CM, et al. Among authors: clark re. Blood. 2011 Jun 16;117(24):6660-8. doi: 10.1182/blood-2010-08-304477. Epub 2011 Apr 13. Blood. 2011. PMID: 21490338 Free article.

4

CIP2A- and SETBP1-mediated PP2A inhibition reveals AKT S473 phosphorylation to be a new biomarker in AML.

Lucas CM, Scott LJ, Carmell N, Holcroft AK, Hills RK, Burnett AK, Clark RE. Lucas CM, et al. Among authors: clark re. Blood Adv. 2018 May 8;2(9):964-968. doi: 10.1182/bloodadvances.2017013615. Blood Adv. 2018. PMID: 29703716 Free PMC article.

5

High CIP2A levels correlate with an antiapoptotic phenotype that can be overcome by targeting BCL-XL in chronic myeloid leukemia.

Lucas CM, Milani M, Butterworth M, Carmell N, Scott LJ, Clark RE, Cohen GM, Varadarajan S. Lucas CM, et al. Among authors: clark re. Leukemia. 2016 Jun;30(6):1273-81. doi: 10.1038/leu.2016.42. Epub 2016 Feb 29. Leukemia. 2016. PMID: 26987906 Free PMC article.

6

Effective dasatinib uptake may occur without human organic cation transporter 1 (hOCT1): implications for the treatment of imatinib-resistant chronic myeloid leukemia.

Giannoudis A, Davies A, Lucas CM, Harris RJ, Pirmohamed M, Clark RE. Giannoudis A, et al. Among authors: clark re. Blood. 2008 Oct 15;112(8):3348-54. doi: 10.1182/blood-2007-10-116236. Epub 2008 Jul 31. Blood. 2008. PMID: 18669873 Free PMC article.

7

Low leukotriene B4 receptor 1 leads to ALOX5 downregulation at diagnosis of chronic myeloid leukemia.

Lucas CM, Harris RJ, Giannoudis A, McDonald E, Clark RE. Lucas CM, et al. Among authors: clark re. Haematologica. 2014 Nov;99(11):1710-5. doi: 10.3324/haematol.2013.101972. Epub 2014 Sep 5. Haematologica. 2014. PMID: 25193960 Free PMC article.

8

c-Myc inhibition decreases CIP2A and reduces BCR-ABL1 tyrosine kinase activity in chronic myeloid leukemia.

Lucas CM, Harris RJ, Giannoudis A, Clark RE. Lucas CM, et al. Among authors: clark re. Haematologica. 2015 May;100(5):e179-82. doi: 10.3324/haematol.2014.115691. Epub 2015 Feb 6. Haematologica. 2015. PMID: 25661443 Free PMC article. No abstract available.

9

Cancerous inhibitor of protein phosphatase 2A (CIP2A) modifies energy metabolism via 5' AMP-activated protein kinase signalling in malignant cells.

Austin JA, Jenkins RE, Austin GM, Glenn MA, Dunn K, Scott L, Lucas CM, Clark RE. Austin JA, et al. Among authors: clark re. Biochem J. 2019 Aug 15;476(15):2255-2269. doi: 10.1042/BCJ20190121. Biochem J. 2019. PMID: 31350330

10

Second generation tyrosine kinase inhibitors prevent disease progression in high-risk (high CIP2A) chronic myeloid leukaemia patients.

Lucas CM, Harris RJ, Holcroft AK, Scott LJ, Carmell N, McDonald E, Polydoros F, Clark RE. Lucas CM, et al. Among authors: clark re. Leukemia. 2015 Jul;29(7):1514-23. doi: 10.1038/leu.2015.71. Epub 2015 Mar 13. Leukemia. 2015. PMID: 25765543

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