Ngo T - Search Results

1

Orphan receptor GPR37L1 remains unliganded.

Ngo T, Wilkins BP, So SS, Keov P, Chahal KK, Finch AM, Coleman JLJ, Kufareva I, Smith NJ. Ngo T, et al. Nat Chem Biol. 2021 Apr;17(4):383-386. doi: 10.1038/s41589-021-00748-z. Epub 2021 Mar 1. Nat Chem Biol. 2021. PMID: 33649602 Free PMC article. No abstract available.

2

5-HT1A receptor pharmacophores to screen for off-target activity of α1-adrenoceptor antagonists.

Ngo T, Nicholas TJ, Chen J, Finch AM, Griffith R. Ngo T, et al. J Comput Aided Mol Des. 2013 Apr;27(4):305-19. doi: 10.1007/s10822-013-9647-5. Epub 2013 Apr 27. J Comput Aided Mol Des. 2013. PMID: 23625023

3

Using constitutive activity to define appropriate high-throughput screening assays for orphan g protein-coupled receptors.

Ngo T, Coleman JL, Smith NJ. Ngo T, et al. Methods Mol Biol. 2015;1272:91-106. doi: 10.1007/978-1-4939-2336-6_7. Methods Mol Biol. 2015. PMID: 25563179

4

Rapid Knockout and Reporter Mouse Line Generation and Breeding Colony Establishment Using EUCOMM Conditional-Ready Embryonic Stem Cells: A Case Study.

Coleman JL, Brennan K, Ngo T, Balaji P, Graham RM, Smith NJ. Coleman JL, et al. Among authors: ngo t. Front Endocrinol (Lausanne). 2015 Jun 30;6:105. doi: 10.3389/fendo.2015.00105. eCollection 2015. Front Endocrinol (Lausanne). 2015. PMID: 26175717 Free PMC article.

5

Identifying ligands at orphan GPCRs: current status using structure-based approaches.

Ngo T, Kufareva I, Coleman JLj, Graham RM, Abagyan R, Smith NJ. Ngo T, et al. Br J Pharmacol. 2016 Oct;173(20):2934-51. doi: 10.1111/bph.13452. Epub 2016 Mar 5. Br J Pharmacol. 2016. PMID: 26837045 Free PMC article. Review.

6

Metalloprotease cleavage of the N terminus of the orphan G protein-coupled receptor GPR37L1 reduces its constitutive activity.

Coleman JL, Ngo T, Schmidt J, Mrad N, Liew CK, Jones NM, Graham RM, Smith NJ. Coleman JL, et al. Among authors: ngo t. Sci Signal. 2016 Apr 12;9(423):ra36. doi: 10.1126/scisignal.aad1089. Sci Signal. 2016. PMID: 27072655

7

Orphan receptor ligand discovery by pickpocketing pharmacological neighbors.

Ngo T, Ilatovskiy AV, Stewart AG, Coleman JL, McRobb FM, Riek RP, Graham RM, Abagyan R, Kufareva I, Smith NJ. Ngo T, et al. Nat Chem Biol. 2017 Feb;13(2):235-242. doi: 10.1038/nchembio.2266. Epub 2016 Dec 19. Nat Chem Biol. 2017. Retraction in: Nat Chem Biol. 2021 Apr;17(4):501. doi: 10.1038/s41589-021-00746-1 PMID: 27992882 Free PMC article. Retracted.

8

The G protein-coupled receptor N-terminus and receptor signalling: N-tering a new era.

Coleman JL, Ngo T, Smith NJ. Coleman JL, et al. Among authors: ngo t. Cell Signal. 2017 May;33:1-9. doi: 10.1016/j.cellsig.2017.02.004. Epub 2017 Feb 8. Cell Signal. 2017. PMID: 28188824 Review.

9

Orphan receptor GPR37L1 contributes to the sexual dimorphism of central cardiovascular control.

Coleman JLJ, Mouat MA, Wu J, Jancovski N, Bassi JK, Chan AY, Humphreys DT, Mrad N, Yu ZY, Ngo T, Iismaa S, Dos Remedios CG, Feneley MP, Allen AM, Graham RM, Smith NJ. Coleman JLJ, et al. Among authors: ngo t. Biol Sex Differ. 2018 Apr 6;9(1):14. doi: 10.1186/s13293-018-0173-y. Biol Sex Differ. 2018. PMID: 29625592 Free PMC article.

10

Structural basis for GPCR-independent activation of heterotrimeric Gi proteins.

Kalogriopoulos NA, Rees SD, Ngo T, Kopcho NJ, Ilatovskiy AV, Sun N, Komives EA, Chang G, Ghosh P, Kufareva I. Kalogriopoulos NA, et al. Among authors: ngo t. Proc Natl Acad Sci U S A. 2019 Aug 13;116(33):16394-16403. doi: 10.1073/pnas.1906658116. Epub 2019 Jul 30. Proc Natl Acad Sci U S A. 2019. PMID: 31363053 Free PMC article.

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