Fleming JR - Search Results

1

Molecular Characterisation of Titin N2A and Its Binding of CARP Reveals a Titin/Actin Cross-linking Mechanism.

Zhou T, Fleming JR, Lange S, Hessel AL, Bogomolovas J, Stronczek C, Grundei D, Ghassemian M, Biju A, Börgeson E, Bullard B, Linke WA, Chen J, Kovermann M, Mayans O. Zhou T, et al. Among authors: fleming jr. J Mol Biol. 2021 Apr 30;433(9):166901. doi: 10.1016/j.jmb.2021.166901. Epub 2021 Feb 27. J Mol Biol. 2021. PMID: 33647290 Free PMC article.

2

CARP interacts with titin at a unique helical N2A sequence and at the domain Ig81 to form a structured complex.

Zhou T, Fleming JR, Franke B, Bogomolovas J, Barsukov I, Rigden DJ, Labeit S, Mayans O. Zhou T, et al. Among authors: fleming jr. FEBS Lett. 2016 Sep;590(18):3098-110. doi: 10.1002/1873-3468.12362. Epub 2016 Sep 2. FEBS Lett. 2016. PMID: 27531639 Free article.

3

Exploration of pathomechanisms triggered by a single-nucleotide polymorphism in titin's I-band: the cardiomyopathy-linked mutation T2580I.

Bogomolovas J, Fleming JR, Anderson BR, Williams R, Lange S, Simon B, Khan MM, Rudolf R, Franke B, Bullard B, Rigden DJ, Granzier H, Labeit S, Mayans O. Bogomolovas J, et al. Among authors: fleming jr. Open Biol. 2016 Sep;6(9):160114. doi: 10.1098/rsob.160114. Open Biol. 2016. PMID: 27683155 Free PMC article.

4

Autophosphorylation Is a Mechanism of Inhibition in Twitchin Kinase.

Williams RM, Franke B, Wilkinson M, Fleming JR, Rigden DJ, Benian GM, Eyers PA, Mayans O. Williams RM, et al. Among authors: fleming jr. J Mol Biol. 2018 Mar 16;430(6):793-805. doi: 10.1016/j.jmb.2018.01.020. Epub 2018 Feb 3. J Mol Biol. 2018. PMID: 29408381

5

Evolutionary Morphing of Tryptophan Synthase: Functional Mechanisms for the Enzymatic Channeling of Indole.

Fleming JR, Schupfner M, Busch F, Baslé A, Ehrmann A, Sterner R, Mayans O. Fleming JR, et al. J Mol Biol. 2018 Dec 7;430(24):5066-5079. doi: 10.1016/j.jmb.2018.10.013. Epub 2018 Oct 25. J Mol Biol. 2018. PMID: 30367843

6

Scalable, Non-denaturing Purification of Phosphoproteins Using Ga³⁺-IMAC: N2A and M1M2 Titin Components as Study case.

Adams M, Fleming JR, Riehle E, Zhou T, Zacharchenko T, Markovic M, Mayans O. Adams M, et al. Among authors: fleming jr. Protein J. 2019 Apr;38(2):181-189. doi: 10.1007/s10930-019-09815-w. Protein J. 2019. PMID: 30719619 Free article.

7

Self-Assembling Proteins as High-Performance Substrates for Embryonic Stem Cell Self-Renewal.

Hill CJ, Fleming JR, Mousavinejad M, Nicholson R, Tzokov SB, Bullough PA, Bogomolovas J, Morgan MR, Mayans O, Murray P. Hill CJ, et al. Among authors: fleming jr. Adv Mater. 2019 Apr;31(17):e1807521. doi: 10.1002/adma.201807521. Epub 2019 Mar 13. Adv Mater. 2019. PMID: 30866118

8

The ZT Biopolymer: A Self-Assembling Protein Scaffold for Stem Cell Applications.

Nesterenko Y, Hill CJ, Fleming JR, Murray P, Mayans O. Nesterenko Y, et al. Among authors: fleming jr. Int J Mol Sci. 2019 Sep 3;20(17):4299. doi: 10.3390/ijms20174299. Int J Mol Sci. 2019. PMID: 31484291 Free PMC article. Review.

9

The importance of chain context in assessing small nucleotide variants in titin: in silico case study of the I10-I11 tandem and its arrhythmic right ventricular cardiomyopathy linked position T2580.

Fleming JR, Rigden DJ, Mayans O. Fleming JR, et al. J Biomol Struct Dyn. 2021 Jul;39(10):3480-3490. doi: 10.1080/07391102.2020.1768148. Epub 2020 May 22. J Biomol Struct Dyn. 2021. PMID: 32396765

10

Exploring Obscurin and SPEG Kinase Biology.

Fleming JR, Rani A, Kraft J, Zenker S, Börgeson E, Lange S. Fleming JR, et al. J Clin Med. 2021 Mar 2;10(5):984. doi: 10.3390/jcm10050984. J Clin Med. 2021. PMID: 33801198 Free PMC article.

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