Kunkel MT - Search Results

1

Protein kinase C fusion proteins are paradoxically loss of function in cancer.

Van AN, Kunkel MT, Baffi TR, Lordén G, Antal CE, Banerjee S, Newton AC. Van AN, et al. Among authors: kunkel mt. J Biol Chem. 2021 Jan-Jun;296:100445. doi: 10.1016/j.jbc.2021.100445. Epub 2021 Feb 20. J Biol Chem. 2021. PMID: 33617877 Free PMC article.

2

Spatio-temporal dynamics of protein kinase B/Akt signaling revealed by a genetically encoded fluorescent reporter.

Kunkel MT, Ni Q, Tsien RY, Zhang J, Newton AC. Kunkel MT, et al. J Biol Chem. 2005 Feb 18;280(7):5581-7. doi: 10.1074/jbc.M411534200. Epub 2004 Dec 6. J Biol Chem. 2005. PMID: 15583002 Free PMC article.

3

Targeting protein kinase C activity reporter to discrete intracellular regions reveals spatiotemporal differences in agonist-dependent signaling.

Gallegos LL, Kunkel MT, Newton AC. Gallegos LL, et al. Among authors: kunkel mt. J Biol Chem. 2006 Oct 13;281(41):30947-56. doi: 10.1074/jbc.M603741200. Epub 2006 Aug 10. J Biol Chem. 2006. PMID: 16901905 Free article.

4

Calcium-dependent regulation of protein kinase D revealed by a genetically encoded kinase activity reporter.

Kunkel MT, Toker A, Tsien RY, Newton AC. Kunkel MT, et al. J Biol Chem. 2007 Mar 2;282(9):6733-42. doi: 10.1074/jbc.M608086200. Epub 2006 Dec 21. J Biol Chem. 2007. PMID: 17189263 Free PMC article.

5

The protein scaffold NHERF-1 controls the amplitude and duration of localized protein kinase D activity.

Kunkel MT, Garcia EL, Kajimoto T, Hall RA, Newton AC. Kunkel MT, et al. J Biol Chem. 2009 Sep 4;284(36):24653-61. doi: 10.1074/jbc.M109.024547. Epub 2009 Jul 6. J Biol Chem. 2009. PMID: 19581308 Free PMC article.

6

Calcium transduces plasma membrane receptor signals to produce diacylglycerol at Golgi membranes.

Kunkel MT, Newton AC. Kunkel MT, et al. J Biol Chem. 2010 Jul 23;285(30):22748-52. doi: 10.1074/jbc.C110.123133. Epub 2010 Jun 2. J Biol Chem. 2010. PMID: 20519514 Free PMC article.

7

Active site inhibitors protect protein kinase C from dephosphorylation and stabilize its mature form.

Gould CM, Antal CE, Reyes G, Kunkel MT, Adams RA, Ziyar A, Riveros T, Newton AC. Gould CM, et al. Among authors: kunkel mt. J Biol Chem. 2011 Aug 19;286(33):28922-28930. doi: 10.1074/jbc.M111.272526. Epub 2011 Jun 29. J Biol Chem. 2011. PMID: 21715334 Free PMC article.

8

Imaging kinase activity at protein scaffolds.

Kunkel MT, Newton AC. Kunkel MT, et al. Methods Mol Biol. 2014;1071:129-37. doi: 10.1007/978-1-62703-622-1_10. Methods Mol Biol. 2014. PMID: 24052385 Free PMC article.

9

Intramolecular conformational changes optimize protein kinase C signaling.

Antal CE, Violin JD, Kunkel MT, Skovsø S, Newton AC. Antal CE, et al. Among authors: kunkel mt. Chem Biol. 2014 Apr 24;21(4):459-469. doi: 10.1016/j.chembiol.2014.02.008. Epub 2014 Mar 13. Chem Biol. 2014. PMID: 24631122 Free PMC article.

10

Protein kinase d inhibitors uncouple phosphorylation from activity by promoting agonist-dependent activation loop phosphorylation.

Kunkel MT, Newton AC. Kunkel MT, et al. Chem Biol. 2015 Jan 22;22(1):98-106. doi: 10.1016/j.chembiol.2014.11.014. Epub 2014 Dec 31. Chem Biol. 2015. PMID: 25556943 Free PMC article.

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