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Discovery of Hydroxyamidine Derivatives as Highly Potent, Selective Indoleamine-2,3-dioxygenase 1 Inhibitors.
Jin F, Hu Q, Fei H, Lv H, Wang S, Gui B, Zhang J, Tu W, Zhang Y, Zhang L, Wan H, Zhang L, Hu B, Yang F, Bai C, He F, Zhang L, Tao W. Jin F, et al. Among authors: zhang l, zhang j, zhang y. ACS Med Chem Lett. 2021 Jan 20;12(2):195-201. doi: 10.1021/acsmedchemlett.0c00443. eCollection 2021 Feb 11. ACS Med Chem Lett. 2021. PMID: 33603965 Free PMC article.
WITHDRAWN: Discovery of SHR1977: A highly potent and selective ROMK inhibitor.
Li X, Zhang Y, Chen Y, He W, Wan H, Zhang L, Hu Q, Feng J, Yuan J, Dong Q, Cao G, Zhang L, He F, Bai C, Tao W. Li X, et al. Among authors: zhang l, zhang y. Bioorg Med Chem Lett. 2016 Jun 27:S0960-894X(16)30683-7. doi: 10.1016/j.bmcl.2016.06.072. Online ahead of print. Bioorg Med Chem Lett. 2016. PMID: 27377326
Discovery of mobocertinib, a potent, oral inhibitor of EGFR exon 20 insertion mutations in non-small cell lung cancer.
Huang WS, Li F, Gong Y, Zhang Y, Youngsaye W, Xu Y, Zhu X, Greenfield MT, Kohlmann A, Taslimi PM, Toms A, Zech SG, Zhou T, Das B, Jang HG, Tugnait M, Ye YE, Gonzalvez F, Baker TE, Nadworny S, Ning Y, Wardwell SD, Zhang S, Gould AE, Hu Y, Lane W, Skene RJ, Zou H, Clackson T, Narasimhan NI, Rivera VM, Dalgarno DC, Shakespeare WC. Huang WS, et al. Among authors: zhang s, zhang y. Bioorg Med Chem Lett. 2023 Jan 15;80:129084. doi: 10.1016/j.bmcl.2022.129084. Epub 2022 Nov 21. Bioorg Med Chem Lett. 2023. PMID: 36423823 Free article.
Discovery of a Novel Benzodiazepine Series of Cbl-b Inhibitors for the Enhancement of Antitumor Immunity.
Boerth JA, Chinn AJ, Schimpl M, Bommakanti G, Chan C, Code EL, Giblin KA, Gohlke A, Hansel CS, Jin M, Kavanagh SL, Lamb ML, Lane JS, Larner CJB, Mfuh AM, Moore RK, Puri T, Quinn TR, Ye M, Robbins KJ, Gancedo-Rodrigo M, Tang H, Walsh J, Ware J, Wrigley GL, Reddy IK, Zhang Y, Grimster NP. Boerth JA, et al. Among authors: zhang y. ACS Med Chem Lett. 2023 Nov 17;14(12):1848-1856. doi: 10.1021/acsmedchemlett.3c00439. eCollection 2023 Dec 14. ACS Med Chem Lett. 2023. PMID: 38116444 Free PMC article.
Accelerated Discovery of Carbamate Cbl-b Inhibitors Using Generative AI Models and Structure-Based Drug Design.
Quinn TR, Giblin KA, Thomson C, Boerth JA, Bommakanti G, Braybrooke E, Chan C, Chinn AJ, Code E, Cui C, Fan Y, Grimster NP, Kohara K, Lamb ML, Ma L, Mfuh AM, Robb GR, Robbins KJ, Schimpl M, Tang H, Ware J, Wrigley GL, Xue L, Zhang Y, Zhu H, Hughes SJ. Quinn TR, et al. Among authors: zhang y. J Med Chem. 2024 Aug 22;67(16):14210-14233. doi: 10.1021/acs.jmedchem.4c01034. Epub 2024 Aug 12. J Med Chem. 2024. PMID: 39132828
Discovery, Optimization, and Biological Evaluation of Arylpyridones as Cbl-b Inhibitors.
Mfuh AM, Boerth JA, Bommakanti G, Chan C, Chinn AJ, Code E, Fricke PJ, Giblin KA, Gohlke A, Hansel C, Hariparsad N, Hughes SJ, Jin M, Kantae V, Kavanagh SL, Lamb ML, Lane J, Moore R, Puri T, Quinn TR, Reddy I, Robb GR, Robbins KJ, Gancedo Rodrigo M, Schimpl M, Singh B, Singh M, Tang H, Thomson C, Walsh JJ, Ware J, Watson IDG, Ye MW, Wrigley GL, Zhang AX, Zhang Y, Grimster NP. Mfuh AM, et al. Among authors: zhang ax, zhang y. J Med Chem. 2024 Jan 25;67(2):1500-1512. doi: 10.1021/acs.jmedchem.3c02083. Epub 2024 Jan 16. J Med Chem. 2024. PMID: 38227216
Pyridones in drug discovery: Recent advances.
Zhang Y, Pike A. Zhang Y, et al. Bioorg Med Chem Lett. 2021 Apr 15;38:127849. doi: 10.1016/j.bmcl.2021.127849. Epub 2021 Feb 18. Bioorg Med Chem Lett. 2021. PMID: 33609656 Review.
Regional antimicrobial resistance gene flow among the One Health sectors in China.
Feng Y, Lu X, Zhao J, Li H, Xu J, Li Z, Wang M, Peng Y, Tian T, Yuan G, Zhang Y, Liu J, Zhang M, Zhu La AT, Qu G, Mu Y, Guo W, Wu Y, Zhang Y, Wang D, Hu Y, Kan B. Feng Y, et al. Among authors: zhang y. Microbiome. 2025 Jan 7;13(1):3. doi: 10.1186/s40168-024-01983-x. Microbiome. 2025. PMID: 39763003
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