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Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions.
Krainer G, Welsh TJ, Joseph JA, Espinosa JR, Wittmann S, de Csilléry E, Sridhar A, Toprakcioglu Z, Gudiškytė G, Czekalska MA, Arter WE, Guillén-Boixet J, Franzmann TM, Qamar S, George-Hyslop PS, Hyman AA, Collepardo-Guevara R, Alberti S, Knowles TPJ. Krainer G, et al. Among authors: alberti s. Nat Commun. 2021 Feb 17;12(1):1085. doi: 10.1038/s41467-021-21181-9. Nat Commun. 2021. PMID: 33597515 Free PMC article.
A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation.
Patel A, Lee HO, Jawerth L, Maharana S, Jahnel M, Hein MY, Stoynov S, Mahamid J, Saha S, Franzmann TM, Pozniakovski A, Poser I, Maghelli N, Royer LA, Weigert M, Myers EW, Grill S, Drechsel D, Hyman AA, Alberti S. Patel A, et al. Among authors: alberti s. Cell. 2015 Aug 27;162(5):1066-77. doi: 10.1016/j.cell.2015.07.047. Cell. 2015. PMID: 26317470 Free article.
Amyloid-like Self-Assembly of a Cellular Compartment.
Boke E, Ruer M, Wühr M, Coughlin M, Lemaitre R, Gygi SP, Alberti S, Drechsel D, Hyman AA, Mitchison TJ. Boke E, et al. Among authors: alberti s. Cell. 2016 Jul 28;166(3):637-650. doi: 10.1016/j.cell.2016.06.051. Cell. 2016. PMID: 27471966 Free PMC article.
ATP as a biological hydrotrope.
Patel A, Malinovska L, Saha S, Wang J, Alberti S, Krishnan Y, Hyman AA. Patel A, et al. Among authors: alberti s. Science. 2017 May 19;356(6339):753-756. doi: 10.1126/science.aaf6846. Science. 2017. PMID: 28522535
Phase separation in biology.
Alberti S. Alberti S. Curr Biol. 2017 Oct 23;27(20):R1097-R1102. doi: 10.1016/j.cub.2017.08.069. Curr Biol. 2017. PMID: 29065286 Free article.
Phase separation of a yeast prion protein promotes cellular fitness.
Franzmann TM, Jahnel M, Pozniakovsky A, Mahamid J, Holehouse AS, Nüske E, Richter D, Baumeister W, Grill SW, Pappu RV, Hyman AA, Alberti S. Franzmann TM, et al. Among authors: alberti s. Science. 2018 Jan 5;359(6371):eaao5654. doi: 10.1126/science.aao5654. Science. 2018. PMID: 29301985
490 results