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NAD+ depletion by type I interferon signaling sensitizes pancreatic cancer cells to NAMPT inhibition.
Moore AM, Zhou L, Cui J, Li L, Wu N, Yu A, Poddar S, Liang K, Abt ER, Kim S, Ghukasyan R, Khachatourian N, Pagano K, Elliott I, Dann AM, Riahi R, Le T, Dawson DW, Radu CG, Donahue TR. Moore AM, et al. Among authors: le t. Proc Natl Acad Sci U S A. 2021 Feb 23;118(8):e2012469118. doi: 10.1073/pnas.2012469118. Proc Natl Acad Sci U S A. 2021. PMID: 33597293 Free PMC article.
Co-targeting of convergent nucleotide biosynthetic pathways for leukemia eradication.
Nathanson DA, Armijo AL, Tom M, Li Z, Dimitrova E, Austin WR, Nomme J, Campbell DO, Ta L, Le TM, Lee JT, Darvish R, Gordin A, Wei L, Liao HI, Wilks M, Martin C, Sadeghi S, Murphy JM, Boulos N, Phelps ME, Faull KF, Herschman HR, Jung ME, Czernin J, Lavie A, Radu CG. Nathanson DA, et al. Among authors: le tm. J Exp Med. 2014 Mar 10;211(3):473-86. doi: 10.1084/jem.20131738. Epub 2014 Feb 24. J Exp Med. 2014. PMID: 24567448 Free PMC article.
[18F]CFA as a clinically translatable probe for PET imaging of deoxycytidine kinase activity.
Kim W, Le TM, Wei L, Poddar S, Bazzy J, Wang X, Uong NT, Abt ER, Capri JR, Austin WR, Van Valkenburgh JS, Steele D, Gipson RM, Slavik R, Cabebe AE, Taechariyakul T, Yaghoubi SS, Lee JT, Sadeghi S, Lavie A, Faull KF, Witte ON, Donahue TR, Phelps ME, Herschman HR, Herrmann K, Czernin J, Radu CG. Kim W, et al. Among authors: le tm. Proc Natl Acad Sci U S A. 2016 Apr 12;113(15):4027-32. doi: 10.1073/pnas.1524212113. Epub 2016 Mar 28. Proc Natl Acad Sci U S A. 2016. PMID: 27035974 Free PMC article.
Metabolic characterization of isocitrate dehydrogenase (IDH) mutant and IDH wildtype gliomaspheres uncovers cell type-specific vulnerabilities.
Garrett M, Sperry J, Braas D, Yan W, Le TM, Mottahedeh J, Ludwig K, Eskin A, Qin Y, Levy R, Breunig JJ, Pajonk F, Graeber TG, Radu CG, Christofk H, Prins RM, Lai A, Liau LM, Coppola G, Kornblum HI. Garrett M, et al. Cancer Metab. 2018 Apr 17;6:4. doi: 10.1186/s40170-018-0177-4. eCollection 2018. Cancer Metab. 2018. PMID: 29692895 Free PMC article.
Lysosome inhibition sensitizes pancreatic cancer to replication stress by aspartate depletion.
Elliott IA, Dann AM, Xu S, Kim SS, Abt ER, Kim W, Poddar S, Moore A, Zhou L, Williams JL, Capri JR, Ghukasyan R, Matsumura C, Tucker DA, Armstrong WR, Cabebe AE, Wu N, Li L, Le TM, Radu CG, Donahue TR. Elliott IA, et al. Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):6842-6847. doi: 10.1073/pnas.1812410116. Epub 2019 Mar 20. Proc Natl Acad Sci U S A. 2019. PMID: 30894490 Free PMC article.
Metabolic Modifier Screen Reveals Secondary Targets of Protein Kinase Inhibitors within Nucleotide Metabolism.
Abt ER, Rosser EW, Durst MA, Lok V, Poddar S, Le TM, Cho A, Kim W, Wei L, Song J, Capri JR, Xu S, Wu N, Slavik R, Jung ME, Damoiseaux R, Czernin J, Donahue TR, Lavie A, Radu CG. Abt ER, et al. Cell Chem Biol. 2020 Feb 20;27(2):197-205.e6. doi: 10.1016/j.chembiol.2019.10.012. Epub 2019 Nov 13. Cell Chem Biol. 2020. PMID: 31734178 Free PMC article.
Development and preclinical pharmacology of a novel dCK inhibitor, DI-87.
Poddar S, Capparelli EV, Rosser EW, Gipson RM, Wei L, Le T, Jung ME, Radu C, Nikanjam M. Poddar S, et al. Among authors: le t. Biochem Pharmacol. 2020 Feb;172:113742. doi: 10.1016/j.bcp.2019.113742. Epub 2019 Dec 6. Biochem Pharmacol. 2020. PMID: 31812677 Free PMC article.
Histone deacetylase inhibition is synthetically lethal with arginine deprivation in pancreatic cancers with low argininosuccinate synthetase 1 expression.
Kim SS, Xu S, Cui J, Poddar S, Le TM, Hayrapetyan H, Li L, Wu N, Moore AM, Zhou L, Yu AC, Dann AM, Elliott IA, Abt ER, Kim W, Dawson DW, Radu CG, Donahue TR. Kim SS, et al. Theranostics. 2020 Jan 1;10(2):829-840. doi: 10.7150/thno.40195. eCollection 2020. Theranostics. 2020. PMID: 31903153 Free PMC article.
5,225 results