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302 results

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Page 1
Fast acting allosteric phosphofructokinase inhibitors block trypanosome glycolysis and cure acute African trypanosomiasis in mice.
McNae IW, Kinkead J, Malik D, Yen LH, Walker MK, Swain C, Webster SP, Gray N, Fernandes PM, Myburgh E, Blackburn EA, Ritchie R, Austin C, Wear MA, Highton AJ, Keats AJ, Vong A, Dornan J, Mottram JC, Michels PAM, Pettit S, Walkinshaw MD. McNae IW, et al. Among authors: swain c. Nat Commun. 2021 Feb 16;12(1):1052. doi: 10.1038/s41467-021-21273-6. Nat Commun. 2021. PMID: 33594070 Free PMC article.
Bifunctional crosslinking ligands for transthyretin.
Mangione PP, Deroo S, Ellmerich S, Bellotti V, Kolstoe S, Wood SP, Robinson CV, Smith MD, Tennent GA, Broadbridge RJ, Council CE, Thurston JR, Steadman VA, Vong AK, Swain CJ, Pepys MB, Taylor GW. Mangione PP, et al. Open Biol. 2015 Sep;5(9):150105. doi: 10.1098/rsob.150105. Open Biol. 2015. PMID: 26400472 Free PMC article.
Novel lactam NK1 antagonists with anti-emetic activity.
Hollingworth GJ, Carlson EJ, Castro JL, Chicchi GG, Clark N, Cooper LC, Dirat O, Salvo JD, Elliott JM, Kilburn R, Kurtz MM, Rycroft W, Tattersall FD, Tsao KL, Swain CJ. Hollingworth GJ, et al. Among authors: swain cj. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1197-201. doi: 10.1016/j.bmcl.2005.11.111. Epub 2005 Dec 27. Bioorg Med Chem Lett. 2006. PMID: 16384700
2-Aryl indole NK1 receptor antagonists: optimisation of indole substitution.
Cooper LC, Chicchi GG, Dinnell K, Elliott JM, Hollingworth GJ, Kurtz MM, Locker KL, Morrison D, Shaw DE, Tsao KL, Watt AP, Williams AR, Swain CJ. Cooper LC, et al. Among authors: swain cj. Bioorg Med Chem Lett. 2001 May 7;11(9):1233-6. doi: 10.1016/s0960-894x(01)00182-2. Bioorg Med Chem Lett. 2001. PMID: 11354384
4,4-Disubstituted cyclohexylamine NK(1) receptor antagonists I.
Elliott JM, Castro JL, Chicchi GG, Cooper LC, Dinnell K, Hollingworth GJ, Ridgill MP, Rycroft W, Kurtz MM, Shaw DE, Swain CJ, Tsao KL, Yang L. Elliott JM, et al. Among authors: swain cj. Bioorg Med Chem Lett. 2002 Jul 8;12(13):1755-8. doi: 10.1016/s0960-894x(02)00249-4. Bioorg Med Chem Lett. 2002. PMID: 12067554
4,4-Disubstituted cyclohexylamine NK(1) receptor antagonists II.
Cooper LC, Carlson EJ, Castro JL, Chicchi GG, Dinnell K, Di Salvo J, Elliott JM, Hollingworth GJ, Kurtz MM, Ridgill MP, Rycroft W, Tsao KL, Swain CJ. Cooper LC, et al. Among authors: swain cj. Bioorg Med Chem Lett. 2002 Jul 8;12(13):1759-62. doi: 10.1016/s0960-894x(02)00250-0. Bioorg Med Chem Lett. 2002. PMID: 12067555
Spirocyclic NK(1) antagonists I: [4.5] and [5.5]-spiroketals.
Seward EM, Carlson E, Harrison T, Haworth KR, Herbert R, Kelleher FJ, Kurtz MM, Moseley J, Owen SN, Owens AP, Sadowski SJ, Swain CJ, Williams BJ. Seward EM, et al. Bioorg Med Chem Lett. 2002 Sep 16;12(18):2515-8. doi: 10.1016/s0960-894x(02)00506-1. Bioorg Med Chem Lett. 2002. PMID: 12182850
Spirocyclic NK(1) antagonists II: [4.5]-spiroethers.
Williams BJ, Cascieri MA, Chicchi GG, Harrison T, Owens AP, Owen SN, Rupniak NM, Tattersall DF, Williams A, Swain CJ. Williams BJ, et al. Bioorg Med Chem Lett. 2002 Oct 7;12(19):2719-22. doi: 10.1016/s0960-894x(02)00509-7. Bioorg Med Chem Lett. 2002. PMID: 12217362
302 results