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Endoplasmic reticulum-associated degradation is required for nephrin maturation and kidney glomerular filtration function.
Yoshida S, Wei X, Zhang G, O'Connor CL, Torres M, Zhou Z, Lin L, Menon R, Xu X, Zheng W, Xiong Y, Otto E, Tang CA, Hua R, Verma R, Mori H, Zhang Y, Hu CA, Liu M, Garg P, Hodgin JB, Sun S, Bitzer M, Qi L. Yoshida S, et al. Among authors: liu m. J Clin Invest. 2021 Apr 1;131(7):e143988. doi: 10.1172/JCI143988. J Clin Invest. 2021. PMID: 33591954 Free PMC article.
Neuronatin regulates pancreatic β cell insulin content and secretion.
Millership SJ, Da Silva Xavier G, Choudhury AI, Bertazzo S, Chabosseau P, Pedroni SM, Irvine EE, Montoya A, Faull P, Taylor WR, Kerr-Conte J, Pattou F, Ferrer J, Christian M, John RM, Latreille M, Liu M, Rutter GA, Scott J, Withers DJ. Millership SJ, et al. Among authors: liu m. J Clin Invest. 2018 Aug 1;128(8):3369-3381. doi: 10.1172/JCI120115. Epub 2018 Jul 9. J Clin Invest. 2018. PMID: 29864031 Free PMC article.
Misfolded proinsulin impairs processing of precursor of insulin receptor and insulin signaling in β cells.
Liu S, Li X, Yang J, Zhu R, Fan Z, Xu X, Feng W, Cui J, Sun J, Liu M. Liu S, et al. Among authors: liu m. FASEB J. 2019 Oct;33(10):11338-11348. doi: 10.1096/fj.201900442R. Epub 2019 Aug 1. FASEB J. 2019. PMID: 31311313 Free PMC article.
These results reveal for the first time that misfolded proinsulin can interact with ProIR in the ER, impairing intracellular processing of ProIR and leading to defective insulin signaling that may contribute to beta-cell failure in both MIDY and T2D.-Liu, S., Li, X., Yang, …
These results reveal for the first time that misfolded proinsulin can interact with ProIR in the ER, impairing intracellular processing of P …
46,093 results
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