Horne CR - Search Results

1

Granulovirus PK-1 kinase activity relies on a side-to-side dimerization mode centered on the regulatory αC helix.

Oliver MR, Horne CR, Shrestha S, Keown JR, Liang LY, Young SN, Sandow JJ, Webb AI, Goldstone DC, Lucet IS, Kannan N, Metcalf P, Murphy JM. Oliver MR, et al. Among authors: horne cr. Nat Commun. 2021 Feb 12;12(1):1002. doi: 10.1038/s41467-021-21191-7. Nat Commun. 2021. PMID: 33579933 Free PMC article.

2

A toolbox for imaging RIPK1, RIPK3, and MLKL in mouse and human cells.

Samson AL, Fitzgibbon C, Patel KM, Hildebrand JM, Whitehead LW, Rimes JS, Jacobsen AV, Horne CR, Gavin XJ, Young SN, Rogers KL, Hawkins ED, Murphy JM. Samson AL, et al. Among authors: horne cr. Cell Death Differ. 2021 Jul;28(7):2126-2144. doi: 10.1038/s41418-021-00742-x. Epub 2021 Feb 15. Cell Death Differ. 2021. PMID: 33589776 Free PMC article.

3

For Whom the Bell Tolls: The Structure of the Dead Kinase, IRAK3.

Horne CR, Murphy JM. Horne CR, et al. Structure. 2021 Mar 4;29(3):197-199. doi: 10.1016/j.str.2021.01.011. Structure. 2021. PMID: 33667374 Free article.

4

Mechanism of NanR gene repression and allosteric induction of bacterial sialic acid metabolism.

Horne CR, Venugopal H, Panjikar S, Wood DM, Henrickson A, Brookes E, North RA, Murphy JM, Friemann R, Griffin MDW, Ramm G, Demeler B, Dobson RCJ. Horne CR, et al. Nat Commun. 2021 Mar 31;12(1):1988. doi: 10.1038/s41467-021-22253-6. Nat Commun. 2021. PMID: 33790291 Free PMC article.

5

Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosis.

Garnish SE, Meng Y, Koide A, Sandow JJ, Denbaum E, Jacobsen AV, Yeung W, Samson AL, Horne CR, Fitzgibbon C, Young SN, Smith PPC, Webb AI, Petrie EJ, Hildebrand JM, Kannan N, Czabotar PE, Koide S, Murphy JM. Garnish SE, et al. Among authors: horne cr. Nat Commun. 2021 Apr 13;12(1):2211. doi: 10.1038/s41467-021-22400-z. Nat Commun. 2021. PMID: 33850121 Free PMC article.

6

SMCHD1's ubiquitin-like domain is required for N-terminal dimerization and chromatin localization.

Gurzau AD, Horne CR, Mok YF, Iminitoff M, Willson TA, Young SN, Blewitt ME, Murphy JM. Gurzau AD, et al. Among authors: horne cr. Biochem J. 2021 Jul 16;478(13):2555-2569. doi: 10.1042/BCJ20210278. Biochem J. 2021. PMID: 34109974 Free PMC article.

7

The intracellular domains of the EphB6 and EphA10 receptor tyrosine pseudokinases function as dynamic signalling hubs.

Liang LY, Roy M, Horne CR, Sandow JJ, Surudoi M, Dagley LF, Young SN, Dite T, Babon JJ, Janes PW, Patel O, Murphy JM, Lucet IS. Liang LY, et al. Among authors: horne cr. Biochem J. 2021 Sep 17;478(17):3351-3371. doi: 10.1042/BCJ20210572. Biochem J. 2021. PMID: 34431498 Free PMC article.

8

Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis.

Meng Y, Davies KA, Fitzgibbon C, Young SN, Garnish SE, Horne CR, Luo C, Garnier JM, Liang LY, Cowan AD, Samson AL, Lessene G, Sandow JJ, Czabotar PE, Murphy JM. Meng Y, et al. Among authors: horne cr. Nat Commun. 2021 Nov 22;12(1):6783. doi: 10.1038/s41467-021-27032-x. Nat Commun. 2021. PMID: 34811356 Free PMC article.

9

Regulation of the EphA2 receptor intracellular region by phosphomimetic negative charges in the kinase-SAM linker.

Lechtenberg BC, Gehring MP, Light TP, Horne CR, Matsumoto MW, Hristova K, Pasquale EB. Lechtenberg BC, et al. Among authors: horne cr. Nat Commun. 2021 Dec 2;12(1):7047. doi: 10.1038/s41467-021-27343-z. Nat Commun. 2021. PMID: 34857764 Free PMC article.

10

Membrane permeabilization is mediated by distinct epitopes in mouse and human orthologs of the necroptosis effector, MLKL.

Sethi A, Horne CR, Fitzgibbon C, Wilde K, Davies KA, Garnish SE, Jacobsen AV, Samson AL, Hildebrand JM, Wardak A, Czabotar PE, Petrie EJ, Gooley PR, Murphy JM. Sethi A, et al. Among authors: horne cr. Cell Death Differ. 2022 Sep;29(9):1804-1815. doi: 10.1038/s41418-022-00965-6. Epub 2022 Mar 9. Cell Death Differ. 2022. PMID: 35264780 Free PMC article.

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