Wu HH - Search Results

1

Pirh2, an E3 ligase, regulates the AIP4-p73 regulatory pathway by modulating AIP4 expression and ubiquitination.

Abou Zeinab R, Wu HH, Abuetabh Y, Leng S, Sergi C, Eisenstat DD, Leng RP. Abou Zeinab R, et al. Among authors: wu hh. Carcinogenesis. 2021 Apr 30;42(4):650-662. doi: 10.1093/carcin/bgab009. Carcinogenesis. 2021. PMID: 33569599 Free PMC article.

2

Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation.

Leng RP, Lin Y, Ma W, Wu H, Lemmers B, Chung S, Parant JM, Lozano G, Hakem R, Benchimol S. Leng RP, et al. Cell. 2003 Mar 21;112(6):779-91. doi: 10.1016/s0092-8674(03)00193-4. Cell. 2003. PMID: 12654245 Free article.

3

UBE4B promotes Hdm2-mediated degradation of the tumor suppressor p53.

Wu H, Pomeroy SL, Ferreira M, Teider N, Mariani J, Nakayama KI, Hatakeyama S, Tron VA, Saltibus LF, Spyracopoulos L, Leng RP. Wu H, et al. Nat Med. 2011 Mar;17(3):347-55. doi: 10.1038/nm.2283. Epub 2011 Feb 13. Nat Med. 2011. PMID: 21317885

4

UBE4B, a ubiquitin chain assembly factor, is required for MDM2-mediated p53 polyubiquitination and degradation.

Wu H, Leng RP. Wu H, et al. Cell Cycle. 2011 Jun 15;10(12):1912-5. doi: 10.4161/cc.10.12.15882. Epub 2011 Jun 15. Cell Cycle. 2011. PMID: 21558803 Free PMC article. Review.

5

Pirh2, a ubiquitin E3 ligase, inhibits p73 transcriptional activity by promoting its ubiquitination.

Wu H, Zeinab RA, Flores ER, Leng RP. Wu H, et al. Mol Cancer Res. 2011 Dec;9(12):1780-90. doi: 10.1158/1541-7786.MCR-11-0157. Epub 2011 Oct 12. Mol Cancer Res. 2011. PMID: 21994467

6

UBE4B: a promising regulatory molecule in neuronal death and survival.

Zeinab RA, Wu H, Sergi C, Leng R. Zeinab RA, et al. Int J Mol Sci. 2012 Dec 10;13(12):16865-79. doi: 10.3390/ijms131216865. Int J Mol Sci. 2012. PMID: 23222733 Free PMC article. Review.

7

Residues 240-250 in the C-terminus of the Pirh2 protein complement the function of the RING domain in self-ubiquitination of the Pirh2 protein.

Abou Zeinab R, Wu H, Sergi C, Leng RP. Abou Zeinab R, et al. PLoS One. 2013 Dec 18;8(12):e82803. doi: 10.1371/journal.pone.0082803. eCollection 2013. PLoS One. 2013. Retraction in: PLoS One. 2021 Aug 26;16(8):e0256909. doi: 10.1371/journal.pone.0256909 PMID: 24367557 Free PMC article. Retracted.

8

MDM2 mediates p73 ubiquitination: a new molecular mechanism for suppression of p73 function.

Wu H, Leng RP. Wu H, et al. Oncotarget. 2015 Aug 28;6(25):21479-92. doi: 10.18632/oncotarget.4086. Oncotarget. 2015. PMID: 26025930 Free PMC article.

9

UBE4B targets phosphorylated p53 at serines 15 and 392 for degradation.

Du C, Wu H, Leng RP. Du C, et al. Oncotarget. 2016 Jan 19;7(3):2823-36. doi: 10.18632/oncotarget.6555. Oncotarget. 2016. PMID: 26673821 Free PMC article.

10

The Regulation of Tumor Suppressor p63 by the Ubiquitin-Proteasome System.

Armstrong SR, Wu H, Wang B, Abuetabh Y, Sergi C, Leng RP. Armstrong SR, et al. Int J Mol Sci. 2016 Dec 6;17(12):2041. doi: 10.3390/ijms17122041. Int J Mol Sci. 2016. PMID: 27929429 Free PMC article. Review.

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