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Loss of TGFβ signaling increases alternative end-joining DNA repair that sensitizes to genotoxic therapies across cancer types.
Liu Q, Palomero L, Moore J, Guix I, Espín R, Aytés A, Mao JH, Paulovich AG, Whiteaker JR, Ivey RG, Iliakis G, Luo D, Chalmers AJ, Murnane J, Pujana MA, Barcellos-Hoff MH. Liu Q, et al. Among authors: chalmers aj. Sci Transl Med. 2021 Feb 10;13(580):eabc4465. doi: 10.1126/scitranslmed.abc4465. Sci Transl Med. 2021. PMID: 33568520 Free PMC article.
Targeting DNA repair in gliomas.
Beckta JM, Bindra RS, Chalmers AJ. Beckta JM, et al. Among authors: chalmers aj. Curr Opin Neurol. 2019 Dec;32(6):878-885. doi: 10.1097/WCO.0000000000000760. Curr Opin Neurol. 2019. PMID: 31592790 Review.
The potential of PARP inhibitors in neuro-oncology.
Carruthers R, Chalmers AJ. Carruthers R, et al. Among authors: chalmers aj. CNS Oncol. 2012 Sep;1(1):85-97. doi: 10.2217/cns.12.13. CNS Oncol. 2012. PMID: 25054302 Free PMC article. Review.
SYSTEMS-2: A randomised phase II study of radiotherapy dose escalation for pain control in malignant pleural mesothelioma.
Ashton M, O'Rourke N, Macleod N, Laird B, Stobo J, Kelly C, Alexander L, Franks K, Moore K, Currie S, Valentine R, Chalmers AJ. Ashton M, et al. Among authors: chalmers aj. Clin Transl Radiat Oncol. 2017 Nov 21;8:45-49. doi: 10.1016/j.ctro.2017.11.004. eCollection 2018 Jan. Clin Transl Radiat Oncol. 2017. PMID: 29594241 Free PMC article.
Replication Stress Drives Constitutive Activation of the DNA Damage Response and Radioresistance in Glioblastoma Stem-like Cells.
Carruthers RD, Ahmed SU, Ramachandran S, Strathdee K, Kurian KM, Hedley A, Gomez-Roman N, Kalna G, Neilson M, Gilmour L, Stevenson KH, Hammond EM, Chalmers AJ. Carruthers RD, et al. Among authors: chalmers aj. Cancer Res. 2018 Sep 1;78(17):5060-5071. doi: 10.1158/0008-5472.CAN-18-0569. Epub 2018 Jul 5. Cancer Res. 2018. PMID: 29976574 Free PMC article.
127 results