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Loss of TGFβ signaling increases alternative end-joining DNA repair that sensitizes to genotoxic therapies across cancer types.
Liu Q, Palomero L, Moore J, Guix I, Espín R, Aytés A, Mao JH, Paulovich AG, Whiteaker JR, Ivey RG, Iliakis G, Luo D, Chalmers AJ, Murnane J, Pujana MA, Barcellos-Hoff MH. Liu Q, et al. Among authors: aytes a. Sci Transl Med. 2021 Feb 10;13(580):eabc4465. doi: 10.1126/scitranslmed.abc4465. Sci Transl Med. 2021. PMID: 33568520 Free PMC article.
NSD2 is a conserved driver of metastatic prostate cancer progression.
Aytes A, Giacobbe A, Mitrofanova A, Ruggero K, Cyrta J, Arriaga J, Palomero L, Farran-Matas S, Rubin MA, Shen MM, Califano A, Abate-Shen C. Aytes A, et al. Nat Commun. 2018 Dec 5;9(1):5201. doi: 10.1038/s41467-018-07511-4. Nat Commun. 2018. PMID: 30518758 Free PMC article.
New perspectives on screening and early detection of endometrial cancer.
Costas L, Frias-Gomez J, Guardiola M, Benavente Y, Pineda M, Pavón MÁ, Martínez JM, Climent M, Barahona M, Canet J, Paytubi S, Salinas M, Palomero L, Bianchi I, Reventós J, Capellà G, Diaz M, Vidal A, Piulats JM, Aytés Á, Ponce J, Brunet J, Bosch FX, Matias-Guiu X, Alemany L, de Sanjosé S; Screenwide Team. Costas L, et al. Among authors: aytes a. Int J Cancer. 2019 Dec 15;145(12):3194-3206. doi: 10.1002/ijc.32514. Epub 2019 Jun 28. Int J Cancer. 2019. PMID: 31199503 Review.
Defining a mutational signature for endometrial cancer screening and early detection.
Costas L, Palomero L, Benavente Y, Guardiola M, Frias-Gomez J, Pavón MÁ, Climent M, Martinez JM, Barahona M, Salinas M, Pineda M, Bianchi I, Reventós J, Capellà G, Diaz M, Vidal A, Piulats JM, Ponce J, Brunet J, Bosch FX, Matias-Guiu X, Alemany L, de Sanjosé S, Aytés Á; Screenwide Team. Costas L, et al. Among authors: aytes a. Cancer Epidemiol. 2019 Aug;61:129-132. doi: 10.1016/j.canep.2019.06.003. Epub 2019 Jun 22. Cancer Epidemiol. 2019. PMID: 31238232
Taxane-induced Attenuation of the CXCR2/BCL-2 Axis Sensitizes Prostate Cancer to Platinum-based Treatment.
Ruiz de Porras V, Wang XC, Palomero L, Marin-Aguilera M, Solé-Blanch C, Indacochea A, Jimenez N, Bystrup S, Bakht M, Conteduca V, Piulats JM, Buisan O, Suarez JF, Pardo JC, Castro E, Olmos D, Beltran H, Mellado B, Martinez-Balibrea E, Font A, Aytes A. Ruiz de Porras V, et al. Among authors: aytes a. Eur Urol. 2021 Jun;79(6):722-733. doi: 10.1016/j.eururo.2020.10.001. Epub 2020 Nov 3. Eur Urol. 2021. PMID: 33153817 Free PMC article.
Interplay between BRCA1 and RHAMM regulates epithelial apicobasal polarization and may influence risk of breast cancer.
Maxwell CA, Benítez J, Gómez-Baldó L, Osorio A, Bonifaci N, Fernández-Ramires R, Costes SV, Guinó E, Chen H, Evans GJ, Mohan P, Català I, Petit A, Aguilar H, Villanueva A, Aytes A, Serra-Musach J, Rennert G, Lejbkowicz F, Peterlongo P, Manoukian S, Peissel B, Ripamonti CB, Bonanni B, Viel A, Allavena A, Bernard L, Radice P, Friedman E, Kaufman B, Laitman Y, Dubrovsky M, Milgrom R, Jakubowska A, Cybulski C, Gorski B, Jaworska K, Durda K, Sukiennicki G, Lubiński J, Shugart YY, Domchek SM, Letrero R, Weber BL, Hogervorst FB, Rookus MA, Collee JM, Devilee P, Ligtenberg MJ, Luijt RB, Aalfs CM, Waisfisz Q, Wijnen J, Roozendaal CE; HEBON; EMBRACE; Easton DF, Peock S, Cook M, Oliver C, Frost D, Harrington P, Evans DG, Lalloo F, Eeles R, Izatt L, Chu C, Eccles D, Douglas F, Brewer C, Nevanlinna H, Heikkinen T, Couch FJ, Lindor NM, Wang X, Godwin AK, Caligo MA, Lombardi G, Loman N, Karlsson P, Ehrencrona H, Wachenfeldt Av; SWE-BRCA; Barkardottir RB, Hamann U, Rashid MU, Lasa A, Caldés T, Andrés R, Schmitt M, Assmann V, Stevens K, Offit K, Curado J, Tilgner H, Guigó R, Aiza G, Brunet J, Castellsagué J, Martrat G, Urruticoechea A, Blanco I, Tihomirova L, Goldgar DE, Buys S, John EM, Mi… See abstract for full author list ➔ Maxwell CA, et al. Among authors: aytes a. PLoS Biol. 2011 Nov;9(11):e1001199. doi: 10.1371/journal.pbio.1001199. Epub 2011 Nov 15. PLoS Biol. 2011. PMID: 22110403 Free PMC article.
BRCA2 and Other DDR Genes in Prostate Cancer.
Nombela P, Lozano R, Aytes A, Mateo J, Olmos D, Castro E. Nombela P, et al. Among authors: aytes a. Cancers (Basel). 2019 Mar 12;11(3):352. doi: 10.3390/cancers11030352. Cancers (Basel). 2019. PMID: 30871108 Free PMC article. Review.
Epigenetic Regulation in Prostate Cancer Progression.
Ruggero K, Farran-Matas S, Martinez-Tebar A, Aytes A. Ruggero K, et al. Among authors: aytes a. Curr Mol Biol Rep. 2018;4(2):101-115. doi: 10.1007/s40610-018-0095-9. Epub 2018 Apr 18. Curr Mol Biol Rep. 2018. PMID: 29888169 Free PMC article. Review.
32 results