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Design and early progress of the Comparison of Anticoagulation and anti-Platelet Therapies for Intracranial Vascular Atherostenosis (CAPTIVA) trial.
Hoh BL, Martin RH, Yeatts SD, Turan TN, Boyette RM, McLaren S, Butler L, Peters KR, Smith J, Cavallari LH, Wabnitz AM, Sabagha N, Unger C, Frasure JS, Broderick JP, Chimowitz MI. Hoh BL, et al. Int J Stroke. 2025 Jan 25:17474930241313301. doi: 10.1177/17474930241313301. Online ahead of print. Int J Stroke. 2025. PMID: 39862061
All subjects receive aspirin (81 mg daily), intensive risk factor management, and will undergo blinded CYP2C19 genotype analysis. The primary goal of the trial is to determine whether rivaroxaban or ticagrelor or both are superior to clopidogrel for lowering the primary en …
All subjects receive aspirin (81 mg daily), intensive risk factor management, and will undergo blinded CYP2C19 genotype analysis. The …
Laminated Two-Terminal All-Perovskite Tandem Solar Cells with Transparent Conductive Adhesives.
Hu H, Pan T, Singh R, Nejand BA, Paetzold UW. Hu H, et al. ACS Appl Mater Interfaces. 2025 Jan 24. doi: 10.1021/acsami.4c19405. Online ahead of print. ACS Appl Mater Interfaces. 2025. PMID: 39856495
Using these two strategies, losses in fill factor (FF) and open-circuit voltage (V(OC)) of the 2T all-perovskite tandem solar cell are reduced, achieving a respectable power conversion efficiency up to 18.2% for the lamination of the all-perovskite tandem solar cell. The l …
Using these two strategies, losses in fill factor (FF) and open-circuit voltage (V(OC)) of the 2T all-perovskite tandem solar cell ar …
An essential role for TASL in mouse autoimmune pathogenesis and Toll-like receptor signaling.
Lau L, Cariaga TA, Chang AB, Lane JH, Purtha WE, Rapaport AS, Hu R, Konno H, Bulloch DN, Rardin MJ, Gibson BW, Devoss J, Ouyang W, Manzanillo PS. Lau L, et al. Nat Commun. 2025 Jan 24;16(1):968. doi: 10.1038/s41467-024-55690-0. Nat Commun. 2025. PMID: 39856038 Free PMC article.
TASL is an immune adaptor that binds to the solute carrier SLC15A4 and facilitates activation of the transcription factor IRF5 during Toll-like receptor (TLR) signaling. Similar to IRF5 and SLC15A4, single nucleotide polymorphisms (SNPs) within TASL have been implicated in …
TASL is an immune adaptor that binds to the solute carrier SLC15A4 and facilitates activation of the transcription factor IRF5 during …
ABO and RhD blood groups as contributors to dyslipidaemia - a cross-sectional study.
Mickelsson M, Ekblom K, Stefansson K, Liv P, Själander A, Näslund U, Hultdin J. Mickelsson M, et al. Lipids Health Dis. 2025 Jan 22;24(1):18. doi: 10.1186/s12944-025-02444-6. Lipids Health Dis. 2025. PMID: 39844181 Free PMC article.
BACKGROUND: The ABO blood group system has shown an association with cardiovascular disease. The susceptibility to CVD is proposed to be partly mediated by dyslipidaemia in non-O individuals. Previous studies are scarce for the RhD blood group, …
BACKGROUND: The ABO blood group system has shown an association with cardiovascular disease. The susceptibility to CVD …
Mineral Stress Drives Loss of Heterochromatin: An Early Harbinger of Vascular Inflammaging and Calcification.
Ho CY, Wu MY, Thammaphet J, Ahmad S, Ho C S J, Draganova L, Anderson G, Jonnalagadda US, Hayward R, Shroff R, Wen WTL, Verhulst A, Foo R, Shanahan CM. Ho CY, et al. Circ Res. 2025 Jan 22. doi: 10.1161/CIRCRESAHA.124.325374. Online ahead of print. Circ Res. 2025. PMID: 39840455
Global analysis of H3K9me3 and H3K27me3 marks and pathway analysis revealed deregulation of insulin signaling and autophagy pathways as well as cross-talking DNA damage and NF-kappaB (nuclear factor kappaB) inflammatory pathways consistent with early activation of the sene …
Global analysis of H3K9me3 and H3K27me3 marks and pathway analysis revealed deregulation of insulin signaling and autophagy pathways as well …
Pembrolizumab and chemotherapy in high-risk, early-stage, ER+/HER2- breast cancer: a randomized phase 3 trial.
Cardoso F, O'Shaughnessy J, Liu Z, McArthur H, Schmid P, Cortes J, Harbeck N, Telli ML, Cescon DW, Fasching PA, Shao Z, Loirat D, Park YH, Fernandez MG, Rubovszky G, Spring L, Im SA, Hui R, Takano T, André F, Yasojima H, Ding Y, Jia L, Karantza V, Tryfonidis K, Bardia A. Cardoso F, et al. Nat Med. 2025 Jan 21. doi: 10.1038/s41591-024-03415-7. Online ahead of print. Nat Med. 2025. PMID: 39838117
However, whether the addition of neoadjuvant pembrolizumab to chemotherapy would improve outcomes in high-risk, early-stage, estrogen receptor-positive/human epidermal growth factor receptor 2-negative (ER(+)/HER2(-)) breast cancer remains unclear. We conducted a double-bl …
However, whether the addition of neoadjuvant pembrolizumab to chemotherapy would improve outcomes in high-risk, early-stage, estrogen recept …
"You wished the ground would open and swallow you up": Expert opinions on shame, the collective, and other cultural considerations for suicide prevention among Asian American and Pacific Islander veterans.
Polzer ER, Rohs CM, Iglesias CD, Mignogna J, Krishnamurti LS, Holliday R, Monteith LL. Polzer ER, et al. Inj Epidemiol. 2025 Jan 20;12(1):5. doi: 10.1186/s40621-025-00560-6. Inj Epidemiol. 2025. PMID: 39833930 Free PMC article.
Fear of bringing shame and dishonor upon one's family was described as a factor which may prevent AAPI Veterans from disclosing mental health concerns and suicide risk and which may prevent them from accessing healthcare services for mental health and suicidality. ...
Fear of bringing shame and dishonor upon one's family was described as a factor which may prevent AAPI Veterans from disclosing menta …
A first-in-human study of JNJ-70218902, a bispecific T-cell-redirecting antibody against TMEFF2 in metastatic castration-resistant prostate cancer.
Calvo E, Doger B, Carles J, Peer A, Sarid D, Eigl BJ, Avadhani A, Yao D, Lin V, Wu S, Jaiprasart P, Loffredo J, Tamegnon M, Xu W, Xie H, Hansen AR. Calvo E, et al. Oncologist. 2025 Jan 17;30(1):oyae313. doi: 10.1093/oncolo/oyae313. Oncologist. 2025. PMID: 39832129 Free PMC article. Clinical Trial.
This study evaluated JNJ-70218902 (JNJ-902), a T-cell redirector targeting transmembrane protein with epidermal growth factor-like and 2 follistatin-like domains 2 (TMEFF2) and cluster of differentiation 3, in mCRPC. ...
This study evaluated JNJ-70218902 (JNJ-902), a T-cell redirector targeting transmembrane protein with epidermal growth factor-like an …
Epigenetic phase variation in the gut microbiome enhances bacterial adaptation.
Ni M, Fan Y, Liu Y, Li Y, Qiao W, Davey LE, Zhang XS, Ksiezarek M, Mead E, Touracheau A, Jiang W, Blaser MJ, Valdivia RH, Fang G. Ni M, et al. bioRxiv [Preprint]. 2025 Jan 11:2025.01.11.632565. doi: 10.1101/2025.01.11.632565. bioRxiv. 2025. PMID: 39829898 Free PMC article. Preprint.
Genome-wide and site-specific ePV have been well characterized in human pathogens' antigenic variation and virulence factor production. However, the role of ePV in facilitating adaptation within the human microbiome remains poorly understood. ...
Genome-wide and site-specific ePV have been well characterized in human pathogens' antigenic variation and virulence factor productio …
Combined negative pressure wound therapy with new wound dressings to repair a ruptured giant omphalocele in a neonate: a case report and literature review.
Hou S, Shi Z, Li X, Yang R, Song Y, Zeng Z. Hou S, et al. BMC Pediatr. 2025 Jan 18;25(1):44. doi: 10.1186/s12887-024-05261-5. BMC Pediatr. 2025. PMID: 39825289 Free PMC article. Review.
Recombinant human basic fibroblast growth factor (Rh-bFGF) was used to heal the wound. No studies have conducted NPWT and new wound dressings healing the wound of ruptured giant omphalocele. ...After halting the NPWT, the wound was managed with Rh-bFGF and VG …
Recombinant human basic fibroblast growth factor (Rh-bFGF) was used to heal the wound. No studies have conducted NPWT and new …
16,396 results
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