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A lipid-anchored neurokinin 1 receptor antagonist prolongs pain relief by a three-pronged mechanism of action targeting the receptor at the plasma membrane and in endosomes.
Mai QN, Shenoy P, Quach T, Retamal JS, Gondin AB, Yeatman HR, Aurelio L, Conner JW, Poole DP, Canals M, Nowell CJ, Graham B, Davis TP, Briddon SJ, Hill SJ, Porter CJH, Bunnett NW, Halls ML, Veldhuis NA. Mai QN, et al. Among authors: nowell cj. J Biol Chem. 2021 Jan-Jun;296:100345. doi: 10.1016/j.jbc.2021.100345. Epub 2021 Jan 28. J Biol Chem. 2021. PMID: 33515548 Free PMC article.
Targeted delivery of mycophenolic acid to the mesenteric lymph node using a triglyceride mimetic prodrug approach enhances gut-specific immunomodulation in mice.
Kochappan R, Cao E, Han S, Hu L, Quach T, Senyschyn D, Ferreira VI, Lee G, Leong N, Sharma G, Lim SF, Nowell CJ, Chen Z, von Andrian UH, Bonner D, Mintern JD, Simpson JS, Trevaskis NL, Porter CJH. Kochappan R, et al. Among authors: nowell cj. J Control Release. 2021 Apr 10;332:636-651. doi: 10.1016/j.jconrel.2021.02.008. Epub 2021 Feb 17. J Control Release. 2021. PMID: 33609620 Free article.
Mesenteric lymphatic dysfunction promotes insulin resistance and represents a potential treatment target in obesity.
Cao E, Watt MJ, Nowell CJ, Quach T, Simpson JS, De Melo Ferreira V, Agarwal S, Chu H, Srivastava A, Anderson D, Gracia G, Lam A, Segal G, Hong J, Hu L, Phang KL, Escott ABJ, Windsor JA, Phillips ARJ, Creek DJ, Harvey NL, Porter CJH, Trevaskis NL. Cao E, et al. Among authors: nowell cj. Nat Metab. 2021 Sep;3(9):1175-1188. doi: 10.1038/s42255-021-00457-w. Epub 2021 Sep 20. Nat Metab. 2021. PMID: 34545251
128 results