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mRNA-1273 efficacy in a severe COVID-19 model: attenuated activation of pulmonary immune cells after challenge.
Meyer M, Wang Y, Edwards D, Smith GR, Rubenstein AB, Ramanathan P, Mire CE, Pietzsch C, Chen X, Ge Y, Cheng WS, Henry C, Woods A, Ma L, Stewart-Jones GBE, Bock KW, Minai M, Nagata BM, Periasamy S, Shi PY, Graham BS, Moore IN, Ramos I, Troyanskaya OG, Zaslavsky E, Carfi A, Sealfon SC, Bukreyev A. Meyer M, et al. Among authors: troyanskaya og. bioRxiv [Preprint]. 2021 Jan 25:2021.01.25.428136. doi: 10.1101/2021.01.25.428136. bioRxiv. 2021. Update in: J Clin Invest. 2021 Oct 15;131(20):e148036. doi: 10.1172/JCI148036 PMID: 33532780 Free PMC article. Updated. Preprint.
Attenuated activation of pulmonary immune cells in mRNA-1273-vaccinated hamsters after SARS-CoV-2 infection.
Meyer M, Wang Y, Edwards D, Smith GR, Rubenstein AB, Ramanathan P, Mire CE, Pietzsch C, Chen X, Ge Y, Cheng WS, Henry C, Woods A, Ma L, Stewart-Jones GB, Bock KW, Minai M, Nagata BM, Periasamy S, Shi PY, Graham BS, Moore IN, Ramos I, Troyanskaya OG, Zaslavsky E, Carfi A, Sealfon SC, Bukreyev A. Meyer M, et al. Among authors: troyanskaya og. J Clin Invest. 2021 Oct 15;131(20):e148036. doi: 10.1172/JCI148036. J Clin Invest. 2021. PMID: 34449440 Free PMC article.
Single nucleus transcriptome and chromatin accessibility of postmortem human pituitaries reveal diverse stem cell regulatory mechanisms.
Zhang Z, Zamojski M, Smith GR, Willis TL, Yianni V, Mendelev N, Pincas H, Seenarine N, Amper MAS, Vasoya M, Cheng WS, Zaslavsky E, Nair VD, Turgeon JL, Bernard DJ, Troyanskaya OG, Andoniadou CL, Sealfon SC, Ruf-Zamojski F. Zhang Z, et al. Among authors: troyanskaya og. Cell Rep. 2022 Mar 8;38(10):110467. doi: 10.1016/j.celrep.2022.110467. Cell Rep. 2022. PMID: 35263594 Free PMC article.
Asymptomatic SARS-CoV-2 Infection Is Associated With Higher Levels of Serum IL-17C, Matrix Metalloproteinase 10 and Fibroblast Growth Factors Than Mild Symptomatic COVID-19.
Soares-Schanoski A, Sauerwald N, Goforth CW, Periasamy S, Weir DL, Lizewski S, Lizewski R, Ge Y, Kuzmina NA, Nair VD, Vangeti S, Marjanovic N, Cappuccio A, Cheng WS, Mofsowitz S, Miller CM, Yu XB, George MC, Zaslavsky E, Bukreyev A, Troyanskaya OG, Sealfon SC, Letizia AG, Ramos I. Soares-Schanoski A, et al. Among authors: troyanskaya og. Front Immunol. 2022 Apr 5;13:821730. doi: 10.3389/fimmu.2022.821730. eCollection 2022. Front Immunol. 2022. PMID: 35479098 Free PMC article.
Pre-infection antiviral innate immunity contributes to sex differences in SARS-CoV-2 infection.
Sauerwald N, Zhang Z, Ramos I, Nair VD, Soares-Schanoski A, Ge Y, Mao W, Alshammary H, Gonzalez-Reiche AS, van de Guchte A, Goforth CW, Lizewski RA, Lizewski SE, Amper MAS, Vasoya M, Seenarine N, Guevara K, Marjanovic N, Miller CM, Nudelman G, Schilling MA, Sealfon RSG, Termini MS, Vangeti S, Weir DL, Zaslavsky E, Chikina M, Wu YN, Van Bakel H, Letizia AG, Sealfon SC, Troyanskaya OG. Sauerwald N, et al. Among authors: troyanskaya og. Cell Syst. 2022 Nov 16;13(11):924-931.e4. doi: 10.1016/j.cels.2022.10.005. Epub 2022 Nov 1. Cell Syst. 2022. PMID: 36323307 Free PMC article.
Multi-objective optimization identifies a specific and interpretable COVID-19 host response signature.
Cappuccio A, Chawla DG, Chen X, Rubenstein AB, Cheng WS, Mao W, Burke TW, Tsalik EL, Petzold E, Henao R, McClain MT, Woods CW, Chikina M, Troyanskaya OG, Sealfon SC, Kleinstein SH, Zaslavsky E. Cappuccio A, et al. Among authors: troyanskaya og. Cell Syst. 2022 Dec 21;13(12):989-1001.e8. doi: 10.1016/j.cels.2022.11.008. Cell Syst. 2022. PMID: 36549275 Free article.
A methylation clock model of mild SARS-CoV-2 infection provides insight into immune dysregulation.
Mao W, Miller CM, Nair VD, Ge Y, Amper MAS, Cappuccio A, George MC, Goforth CW, Guevara K, Marjanovic N, Nudelman G, Pincas H, Ramos I, Sealfon RSG, Soares-Schanoski A, Vangeti S, Vasoya M, Weir DL, Zaslavsky E; Biobank Team; Kim-Schulze S, Gnjatic S, Merad M, Letizia AG, Troyanskaya OG, Sealfon SC, Chikina M. Mao W, et al. Among authors: troyanskaya og. Mol Syst Biol. 2023 May 9;19(5):e11361. doi: 10.15252/msb.202211361. Epub 2023 Mar 15. Mol Syst Biol. 2023. PMID: 36919946 Free PMC article.
Blood RNA alternative splicing events as diagnostic biomarkers for infectious disease.
Zhang Z, Sauerwald N, Cappuccio A, Ramos I, Nair VD, Nudelman G, Zaslavsky E, Ge Y, Gaitas A, Ren H, Brockman J, Geis J, Ramalingam N, King D, McClain MT, Woods CW, Henao R, Burke TW, Tsalik EL, Goforth CW, Lizewski RA, Lizewski SE, Weir DL, Letizia AG, Sealfon SC, Troyanskaya OG. Zhang Z, et al. Among authors: troyanskaya og. Cell Rep Methods. 2023 Jan 12;3(2):100395. doi: 10.1016/j.crmeth.2023.100395. eCollection 2023 Feb 27. Cell Rep Methods. 2023. PMID: 36936082 Free PMC article.
Automated single-cell omics end-to-end framework with data-driven batch inference.
Wang Y, Thistlethwaite W, Tadych A, Ruf-Zamojski F, Bernard DJ, Cappuccio A, Zaslavsky E, Chen X, Sealfon SC, Troyanskaya OG. Wang Y, et al. Among authors: troyanskaya og. bioRxiv [Preprint]. 2024 Jun 20:2023.11.01.564815. doi: 10.1101/2023.11.01.564815. bioRxiv. 2024. Update in: Cell Syst. 2024 Oct 16;15(10):982-990.e5. doi: 10.1016/j.cels.2024.09.003 PMID: 37961197 Free PMC article. Updated. Preprint.
172 results